HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15611048
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FYVE~VHS, VHS~VHS
Common GO terms	GO:0005764 - lysosome GO:0006622 - protein targeting to lysosome GO:0031901 - early endosome membrane GO:0035091 - phosphatidylinositol binding GO:0043130 - ubiquitin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 723
+	Hs
		160224 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Hs
		1348855 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		GGA3_HUMAN (1-723): 3.49e-148: 451: 100.00
+	Hs
		159801 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		TOM1_HUMAN (7-402): 8.19e-85: 278: 22.76
+	Hs
		159809 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		160122 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Mm
		292346 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		STAM2_MOUSE (1-463): 5.11e-79: 264: 15.63
+	Hs
		159808 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		TM1L1_HUMAN (6-473): 8.9e-63: 219: 16.50
+	Hs
		159777 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Ce
		1089151 Q17796_CAEEL (5-737): 9.07e-93: 307: 33.11		Q17796_CAEEL (6-400): 1.98e-66: 235: 14.21
+	Ce
		136435 Q17796_CAEEL (5-737): 9.07e-93: 307: 33.11		STAM1_CAEEL (4-462): 8.67e-54: 194: 15.76
+	Hs
		160223 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83
+	Hs
		277104 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Hs
		241128 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		TM1L1_HUMAN (6-473): 8.9e-63: 219: 16.50
+	Dm
		1280459 HRS_DROME (6-672): 1.2e-54: 203: 35.98		Q9XTL2_DROME (7-544): 4.73e-56: 205: 14.79
+	Mm
		1307830 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		HGS_MOUSE (8-144): 9.66e-09: 60.8: 31.43
+	Hs
		212669 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		AP1G1_HUMAN (503-720): 2.89e-51: 193: 26.96
+	Hs
		1348858 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83