HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31501420, 38280479
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 504
+	Hs
		160535 IRS4_HUMAN (1-1257): 0: 1632: 100.00		HUWE1_HUMAN (76-504): 3.07e-59: 213: 10.09
+	Hs
		160610 IRS4_HUMAN (1-1257): 0: 1632: 100.00		WWTR1_HUMAN (39-504): 6.42e-58: 199: 39.66
+	Rn
		98920 F1MAL5_RAT (601-1085): 2.46e-23: 109: 22.37		NEDD4_RAT (28-504): 1.38e-112: 355: 16.77
+	Hs
		861856 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		NEDD4_HUMAN (40-504): 3.86e-95: 315: 19.26
+	Hs
		772472 IRS1_HUMAN (685-1104): 4.2e-16: 86.4: 19.17		NEDD4_HUMAN (40-504): 3.86e-95: 315: 19.26