HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: DCAF8 (Q5TAQ9)
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
Gene: DCAF8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26673895, 22500989
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 597
+	Xl
		1155582 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		DCAF8_XENLA (1-551): 6.14e-115: 356: 83.27
+	Hs
		163094 XPO1_HUMAN (1-1071): 0: 1022: 100.00		FBXW7_HUMAN (312-594): 7.67e-52: 191: 12.28
+	Hs
		163237 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TBL1R_HUMAN (323-595): 1.19e-49: 181: 12.63
+	Hs
		162990 XPO1_HUMAN (1-1071): 0: 1022: 100.00		WDTC1_HUMAN (405-597): 4.23e-46: 174: 30.30
+	Mm
		1160043 XPO1_MOUSE (1-1071): 0: 1019: 98.04		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Hs
		163123 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SNR40_HUMAN (83-358): 2.66e-47: 171: 14.69
+	Hs
		162576 XPO1_HUMAN (1-1071): 0: 1022: 100.00		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		162824 XPO1_HUMAN (1-1071): 0: 1022: 100.00		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Hs
		162254 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TBL1X_HUMAN (365-588): 1.06e-37: 149: 9.87
+	Xl
		1155597 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6NS11_XENLA (423-597): 1.05e-41: 161: 30.56
+	Xl
		1150112 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6DCY8_XENLA (108-359): 3.32e-33: 131: 17.18
+	Xl
		1155635 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6PCE6_XENLA (2-228): 1.87e-24: 110: 15.19
+	Hs
		162900 XPO1_HUMAN (1-1071): 0: 1022: 100.00		WDR82_HUMAN (329-546): 8.72e-13: 71.4: 10.90
+	Xl
		1144990 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		WD82A_XENLA (369-521): 6.47e-15: 77.9: 18.83
+	Xl
		1155663 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		TB1RA_XENLA (499-583): 5.61e-09: 60.7: 10.10
+	Mm
		1237186 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		DCAF8_MOUSE (1-597): 4.88e-127: 387: 95.49
+	Mm
		1193416 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		DCAF5_MOUSE (153-542): 1.05e-78: 269: 22.72
+	Hs
		207976 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		FBXW7_HUMAN (312-594): 7.67e-52: 191: 12.28
+	Mm
		1194852 TNPO2_MOUSE (33-1045): 3.84e-129: 416: 14.35		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Mm
		903678 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		WDR5_MOUSE (278-585): 2.83e-45: 165: 12.18