HitPredict

Interactor 1: KCNG4 (Q8TDN1)
Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4)
Gene: KCNG4

Interactor 2: KCNB2 (Q92953)
Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
Gene: KCNB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	19074135, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BTB_2~BTB_2, Ion_trans~Ion_trans
Common GO terms	GO:0005251 - delayed rectifier potassium channel activity GO:0005886 - plasma membrane GO:0008076 - voltage-gated potassium channel complex GO:0051260 - protein homooligomerization GO:0071805 - potassium ion transmembrane transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 911
+	Hs
		1273152 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNB2_HUMAN (1-911): 0: 738: 100.00
+	Hs
		1058651 KCNG2_HUMAN (59-470): 1.9e-151: 442: 61.17		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Hs
		1058643 KCNG4_HUMAN (1-519): 3.89e-150: 441: 100.00		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Hs
		1058645 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Hs
		1058633 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Mm
		61654 KCNB2_MOUSE (31-519): 2.15e-141: 431: 36.40		KCNB1_MOUSE (6-911): 0: 608: 61.40
+	Hs
		1273155 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNS3_HUMAN (29-503): 7.52e-130: 401: 41.27
+	Hs
		1058647 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNS3_HUMAN (29-503): 7.52e-130: 401: 41.27
+	Hs
		1273157 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNF1_HUMAN (22-502): 5.5e-128: 396: 37.73
+	Hs
		1273162 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNG1_HUMAN (2-440): 2.6e-123: 385: 40.31
+	Hs
		1058649 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNG1_HUMAN (2-440): 2.6e-123: 385: 40.31
+	Hs
		1058644 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNV2_HUMAN (17-438): 1.3e-111: 355: 39.22
+	Hs
		1161871 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNV1_HUMAN (25-467): 2.1e-108: 345: 42.95
+	Hs
		1058636 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNV1_HUMAN (25-467): 2.1e-108: 345: 42.95
+	Hs
		1251106 KCNB2_HUMAN (31-519): 2.01e-140: 429: 36.20		KCNG3_HUMAN (37-441): 6.64e-92: 299: 39.01
+	Hs
		1058642 KCNB1_HUMAN (35-519): 1.17e-139: 425: 35.08		KCNG3_HUMAN (37-441): 6.64e-92: 299: 39.01