HitPredict

Interactor 1: NRP1 (O14786)
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Gene: NRP1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 19857463, 11948691, 11886873, 26037503, 21653826, 17222790, 16763549
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~MAM, MAM~ig
Common GO terms GO:0001525 - angiogenesis
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002042 - cell migration involved in sprouting angiogenesis
and 17 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 923
Hs

1 1356
+ Hs
+ Mm
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Service provided by Combinatics, Japan

Last updated: 11Aug2025