Protein: TAF1
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)

Gene: TAF1
Organism: Homo sapiens
Interactions: 225
UniProt ID: P21675

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

589777

TBP
TATA-box-binding protein

19

14

Small-scale

0.986

High

600159

TAF7L
Transcription initiation factor TFIID subunit 7-like

4

7

Small-scale

0.897

High

600149

TAF7
Transcription initiation factor TFIID subunit 7

4

7

Small-scale

0.884

High

600164

TAF3
Transcription initiation factor TFIID subunit 3

3

20

Small-scale

0.847

High

600145

BRD3
Bromodomain-containing protein 3

2

19

High-throughput

0.776

High

600081

BRD2
Bromodomain-containing protein 2

2

20

High-throughput

0.754

High

600176

TAF8
Transcription initiation factor TFIID subunit 8

6

6

Small-scale

0.730

High

600091

T2FA
General transcription factor IIF subunit 1

5

1

Small-scale

0.721

High

414166

RB
Retinoblastoma-associated protein

4

6

Small-scale

0.714

High

600260

ASF1A
Histone chaperone ASF1A

1

7

Small-scale

0.710

High

600123

H31
Histone H3.1

5

20

Small-scale

0.707

High

600242

BRWD1
Bromodomain and WD repeat-containing protein 1

1

19

High-throughput

0.698

High

600135

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.691

High

124165

TAF4
Transcription initiation factor TFIID subunit 4

4

18

Small-scale

0.689

High

600119

H4
Histone H4

4

20

Small-scale

0.683

High

600101

TAF6
Transcription initiation factor TFIID subunit 6

4

15

Small-scale

0.680

High

600166

TAF2
Transcription initiation factor TFIID subunit 2

4

8

Small-scale

0.680

High

600146

TAF5
Transcription initiation factor TFIID subunit 5

4

20

Small-scale

0.676

High

600234

TAF9B
Transcription initiation factor TFIID subunit 9B

3

14

Small-scale

0.656

High

600199

TAF4B
Transcription initiation factor TFIID subunit 4B

3

20

Small-scale

0.646

High

600136

TAF10
Transcription initiation factor TFIID subunit 10

3

14

Small-scale

0.646

High

600147

TAF13
Transcription initiation factor TFIID subunit 13

3

6

Small-scale

0.640

High

600155

TAF9
Transcription initiation factor TFIID subunit 9

3

14

Small-scale

0.640

High

600117

WDR5
WD repeat-containing protein 5

3

19

Small-scale

0.633

High

487129

ANDR
Androgen receptor

2

20

Small-scale

0.631

High

600079

CCND1
G1/S-specific cyclin-D1

2

17

Small-scale

0.629

High

386088

P53
Cellular tumor antigen p53

2

20

Small-scale

0.624

High

243928

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.618

High

600077

TAF1
Transcription initiation factor TFIID subunit 1

1

20

Small-scale

0.618

High

600103

SMCA2
Probable global transcription activator SNF2L2

1

20

Small-scale

0.618

High

600110

BRPF1
Peregrin

1

19

High-throughput

0.618

High

600118

TBPL1
TATA box-binding protein-like 1

1

14

High-throughput

0.618

High

600130

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.618

High

600148

TAF11
Transcription initiation factor TFIID subunit 11

1

5

Small-scale

0.618

High

600197

PHIP
PH-interacting protein

1

18

High-throughput

0.618

High

600203

PF21A
PHD finger protein 21A

1

20

High-throughput

0.618

High

600227

BRD8
Bromodomain-containing protein 8

1

19

High-throughput

0.618

High

600253

BRPF3
Bromodomain and PHD finger-containing protein 3

1

20

High-throughput

0.618

High

600258

PHF8
Histone lysine demethylase PHF8

1

14

Small-scale

0.618

High

600152

TAF12
Transcription initiation factor TFIID subunit 12

2

11

High-throughput

0.611

High

394114

A4
Amyloid-beta precursor protein

2

6

High-throughput

0.608

High

600128

MDM2
E3 ubiquitin-protein ligase Mdm2

2

6

Small-scale

0.595

High

600191

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

0

High-throughput

0.585

High

345919

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

600251

RCOR1
REST corepressor 1

2

20

High-throughput

0.584

High

600078

PAX3
Paired box protein Pax-3

1

18

Small-scale

0.578

High

600156

H31T
Histone H3.1t

2

20

Small-scale

0.563

High

600250

LHX3
LIM/homeobox protein Lhx3

1

15

Small-scale

0.561

High

567634

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.552

High

296506

KPCD3
Serine/threonine-protein kinase D3

1

11

High-throughput

0.541

High

600080

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.541

High

600100

RBP2
E3 SUMO-protein ligase RanBP2

1

4

High-throughput

0.541

High

600107

TTC3
E3 ubiquitin-protein ligase TTC3

1

12

High-throughput

0.541

High

600111

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

9

High-throughput

0.541

High

600115

MAX
Protein max

1

20

High-throughput

0.541

High

600162

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

15

High-throughput

0.541

High

600189

CLIP4
CAP-Gly domain-containing linker protein 4

1

5

High-throughput

0.541

High

600208

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.541

High

313391

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.536

High

600096

MAGA9
Melanoma-associated antigen 9

1

7

High-throughput

0.536

High

600098

CDK8
Cyclin-dependent kinase 8

1

19

High-throughput

0.536

High

600158

TFDP3
Transcription factor Dp family member 3

1

2

High-throughput

0.536

High

600214

NPAS1
Neuronal PAS domain-containing protein 1

1

20

High-throughput

0.536

High

600230

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.536

High

600112

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

600142

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

245665

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

600163

GFI1B
Zinc finger protein Gfi-1b

1

9

High-throughput

0.508

High

600238

BRMS1
Breast cancer metastasis-suppressor 1

1

5

Small-scale

0.508

High

345327

FOS
Protein c-Fos

1

20

Small-scale

0.501

High

401413

JUN
Transcription factor Jun

1

20

Small-scale

0.501

High

600116

SUMO2
Small ubiquitin-related modifier 2

1

13

High-throughput

0.501

High

600121

UBC9
SUMO-conjugating enzyme UBC9

1

12

Small-scale

0.501

High

600129

H11
Histone H1.1

1

11

Small-scale

0.501

High

600131

TF65
Transcription factor p65

1

19

Small-scale

0.501

High

277821

DYSF
Dysferlin

1

5

High-throughput

0.494

High

279275

DNJB5
DnaJ homolog subfamily B member 5

1

7

High-throughput

0.494

High

574496

ITB5
Integrin beta-5

1

2

High-throughput

0.494

High

600109

MYOM2
Myomesin-2

1

5

High-throughput

0.494

High

600225

DOCK9
Dedicator of cytokinesis protein 9

1

1

High-throughput

0.494

High

452621

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

600094

LIFR
Leukemia inhibitory factor receptor

1

3

High-throughput

0.489

High

600195

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

600200

KIFA3
Kinesin-associated protein 3

1

20

High-throughput

0.489

High

600262

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

600087

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.480

High

600106

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

118201

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

122494

MEN1
Menin

1

5

Small-scale

0.479

High

179546

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

13

High-throughput

0.479

High

232000

KDM1A
Lysine-specific histone demethylase 1A

1

14

High-throughput

0.479

High

304026

UBR5
E3 ubiquitin-protein ligase UBR5

1

12

High-throughput

0.479

High

309660

KAT7
Histone acetyltransferase KAT7

1

20

High-throughput

0.479

High

312015

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

20

High-throughput

0.479

High

313638

ZIC2
Zinc finger protein ZIC 2

1

11

High-throughput

0.479

High

319718

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

485105

GLI3
Transcriptional activator GLI3

1

12

High-throughput

0.479

High

523519

XRCC6
X-ray repair cross-complementing protein 6

1

14

High-throughput

0.479

High

600082

TYY1
Transcriptional repressor protein YY1

1

19

High-throughput

0.479

High

600083

RBTN2
Rhombotin-2

1

17

Small-scale

0.479

High

600084

PAX6
Paired box protein Pax-6

1

14

Small-scale

0.479

High

600085

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

Small-scale

0.479

High

600086

RBL1
Retinoblastoma-like protein 1

1

6

Small-scale

0.479

High

600088

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.479

High

600089

CDC27
Cell division cycle protein 27 homolog

1

20

Small-scale

0.479

High

600090

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

600092

COIL
Coilin

1

3

High-throughput

0.479

High

600093

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

600095

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

19

High-throughput

0.479

High

600097

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

600099

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

600102

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.479

High

600104

IRAK1
Interleukin-1 receptor-associated kinase 1

1

4

High-throughput

0.479

High

600105

JAK3
Tyrosine-protein kinase JAK3

1

20

High-throughput

0.479

High

600108

ATN1
Atrophin-1

1

13

High-throughput

0.479

High

600113

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

600114

YBEY
Endoribonuclease YbeY

1

1

High-throughput

0.479

High

600122

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.479

High

600125

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

600126

H33
Histone H3.3

1

20

High-throughput

0.479

High

600134

RBL2
Retinoblastoma-like protein 2

1

6

Small-scale

0.479

High

600137

ATM
Serine-protein kinase ATM

1

20

High-throughput

0.479

High

600138

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

600139

PEX6
Peroxisomal ATPase PEX6

1

11

High-throughput

0.479

High

600141

KEAP1
Kelch-like ECH-associated protein 1

1

3

High-throughput

0.479

High

600150

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

600151

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

600153

B2LA1
Bcl-2-related protein A1

1

6

Small-scale

0.479

High

600157

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

7

High-throughput

0.479

High

600160

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

3

High-throughput

0.479

High

600161

ZN362
Zinc finger protein 362

1

6

High-throughput

0.479

High

600167

GLD2
Poly(A) RNA polymerase GLD2

1

5

High-throughput

0.479

High

600168

RICTR
Rapamycin-insensitive companion of mTOR

1

7

High-throughput

0.479

High

600169

TSSK4
Testis-specific serine/threonine-protein kinase 4

1

3

High-throughput

0.479

High

600170

SAMD1
Sterile alpha motif domain-containing protein 1

1

19

High-throughput

0.479

High

600174

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

600175

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

2

High-throughput

0.479

High

600177

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

16

Small-scale

0.479

High

600178

LDB1
LIM domain-binding protein 1

1

2

Small-scale

0.479

High

600179

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

600180

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

600181

DHX40
Probable ATP-dependent RNA helicase DHX40

1

13

High-throughput

0.479

High

600184

SMC5
Structural maintenance of chromosomes protein 5

1

20

High-throughput

0.479

High

600185

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.479

High

600187

RCOR2
REST corepressor 2

1

20

High-throughput

0.479

High

600188

ABCA7
Phospholipid-transporting ATPase ABCA7

1

2

High-throughput

0.479

High

600192

COQ8A
Atypical kinase COQ8A, mitochondrial

1

6

High-throughput

0.479

High

600194

FEZF2
Fez family zinc finger protein 2

1

7

High-throughput

0.479

High

600202

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

20

High-throughput

0.479

High

600204

SIPA1
Signal-induced proliferation-associated protein 1

1

2

High-throughput

0.479

High

600205

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

600209

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

600210

WRIP1
ATPase WRNIP1

1

7

High-throughput

0.479

High

600211

SIN3A
Paired amphipathic helix protein Sin3a

1

5

Small-scale

0.479

High

600212

HTF4
Transcription factor 12

1

13

High-throughput

0.479

High

600213

FEV
Protein FEV

1

20

High-throughput

0.479

High

600215

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

600219

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

600220

DDX23
Probable ATP-dependent RNA helicase DDX23

1

13

High-throughput

0.479

High

600221

GNL3
Guanine nucleotide-binding protein-like 3

1

10

High-throughput

0.479

High

600222

DDA1
DET1- and DDB1-associated protein 1

1

4

High-throughput

0.479

High

600223

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

600226

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

5

High-throughput

0.479

High

600228

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

600229

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

600231

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

600233

SP110
Sp110 nuclear body protein

1

20

High-throughput

0.479

High

600237

TF7L1
Transcription factor 7-like 1

1

20

High-throughput

0.479

High

600239

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

600245

UCKL1
Uridine-cytidine kinase-like 1

1

1

High-throughput

0.479

High

600246

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

2

High-throughput

0.479

High

600247

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

600248

MYEF2
Myelin expression factor 2

1

10

High-throughput

0.479

High

600249

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

600252

NUP50
Nuclear pore complex protein Nup50

1

8

High-throughput

0.479

High

600255

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

1

High-throughput

0.479

High

600256

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

High-throughput

0.479

High

600257

AKP8L
A-kinase anchor protein 8-like

1

10

High-throughput

0.479

High

600261

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

600133

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.470

High

600186

BD1L2
Biorientation of chromosomes in cell division protein 1-like 2

1

0

High-throughput

0.458

High

600193

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.458

High

600218

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.458

High

600224

BEX2
Protein BEX2

1

0

Small-scale

0.458

High

600132

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.457

High

600240

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

600140

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

11

Small-scale

0.439

High

63991

SPDE4
Speedy protein E4

1

2

High-throughput

0.437

High

153214

ACOT8
Acyl-coenzyme A thioesterase 8

1

3

High-throughput

0.437

High

215427

SCO2
Protein SCO2 homolog, mitochondrial

1

6

High-throughput

0.437

High

433124

LAMB1
Laminin subunit beta-1

1

6

High-throughput

0.437

High

441011

CD14
Monocyte differentiation antigen CD14

1

1

High-throughput

0.437

High

600120

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.437

High

600124

3BP2
SH3 domain-binding protein 2

1

2

High-throughput

0.437

High

600127

BORG5
Cdc42 effector protein 1

1

1

High-throughput

0.437

High

600143

RCN2
Reticulocalbin-2

1

20

High-throughput

0.437

High

600144

GSE1
Genetic suppressor element 1

1

3

High-throughput

0.437

High

600165

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

1

High-throughput

0.437

High

600171

UNC5D
Netrin receptor UNC5D

1

2

High-throughput

0.437

High

600172

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

600173

AN13D
Ankyrin repeat domain-containing protein 13D

1

7

High-throughput

0.437

High

600182

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.437

High

600190

S4A11
Solute carrier family 4 member 11

1

2

High-throughput

0.437

High

600196

FBF1
Fas-binding factor 1

1

15

High-throughput

0.437

High

600201

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

6

High-throughput

0.437

High

600207

TMX3
Protein disulfide-isomerase TMX3

1

9

High-throughput

0.437

High

600217

CAB45
45 kDa calcium-binding protein

1

19

High-throughput

0.437

High

600232

FBRS
Probable fibrosin-1

1

4

High-throughput

0.437

High

600235

K1549
UPF0606 protein KIAA1549

1

17

High-throughput

0.437

High

600236

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

600243

EMIL3
EMILIN-3

1

10

High-throughput

0.437

High

600244

TM248
Transmembrane protein 248

1

1

High-throughput

0.437

High

600259

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

6

High-throughput

0.437

High

600263

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

4

High-throughput

0.437

High

600154

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.282

High

600183

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

600216

SPT25
Spermatogenesis-associated protein 25

1

0

High-throughput

0.279

Low

600241

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.279

Low

80914

B6ZDN3
Doublecortin domain containing 1

1

0

High-throughput

0.249

Low

534162

HRES1
Putative HTLV-1-related endogenous sequence

1

0

High-throughput

0.249

Low

600198

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.249

Low

600206

PAGE5
P antigen family member 5

1

0

High-throughput

0.249

Low

600254

INTU
Protein inturned

1

0

High-throughput

0.249

Low

484545

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024