HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: RND1 (Q92730)
Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)
Gene: RND1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	12730235, 29040270
Identification Methods	two hybrid, isothermal titration calorimetry, molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0007162 - negative regulation of cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1838 Hs			1 232
+	Hs
		165183 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RND3_HUMAN (1-232): 1.75e-100: 293: 58.20
+	Hs
		165180 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		CDC42_HUMAN (11-197): 1.18e-80: 241: 37.43
+	Hs
		165172 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RND2_HUMAN (12-232): 9.62e-80: 240: 53.15
+	Hs
		165187 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC1_HUMAN (11-200): 6.76e-80: 239: 38.42
+	Hs
		165179 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC3_HUMAN (11-188): 5.54e-77: 232: 39.89
+	Hs
		165155 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC2_HUMAN (11-201): 1.34e-76: 230: 38.22
+	Hs
		165182 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOA_HUMAN (15-198): 2.7e-76: 230: 42.94
+	Hs
		165189 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOG_HUMAN (11-198): 1.56e-76: 230: 37.77
+	Hs
		165146 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOC_HUMAN (13-184): 4.59e-50: 163: 46.51
+	Hs
		165185 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOB_HUMAN (13-190): 2.91e-49: 161: 44.94
+	Hs
		120208 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOD_HUMAN (6-189): 1.79e-48: 160: 40.76
+	Hs
		165255 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOF_HUMAN (1-189): 2.33e-44: 149: 40.21
+	Hs
		894567 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		CDC42_HUMAN (11-197): 1.18e-80: 241: 37.43
+	Hs
		925714 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC1_HUMAN (11-200): 6.76e-80: 239: 38.42
+	Hs
		892670 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC3_HUMAN (11-188): 5.54e-77: 232: 39.89
+	Hs
		545690 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC2_HUMAN (11-201): 1.34e-76: 230: 38.22
+	Hs
		901031 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOA_HUMAN (15-198): 2.7e-76: 230: 42.94
+	Hs
		436563 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOC_HUMAN (13-184): 4.59e-50: 163: 46.51
+	Hs
		916056 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOB_HUMAN (13-190): 2.91e-49: 161: 44.94
+	Hs
		120703 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOD_HUMAN (6-189): 1.79e-48: 160: 40.76