HitPredict

Interactor 1: SR140 (O15042)
U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140)
Gene: U2SURP

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	23403292, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1029 Hs			1 595
+	Hs
		165413 SR140_HUMAN (1-1019): 0: 701: 100.00		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		165386 SR140_HUMAN (1-1019): 0: 701: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		369739 PAP1L_HUMAN (62-515): 2.4e-46: 178: 12.45		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369534 PABP4_HUMAN (269-363): 1.28e-19: 96.2: 25.26		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368886 PABP1_HUMAN (265-363): 6.71e-19: 93.9: 25.25		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370422 PABP3_HUMAN (265-363): 8.17e-17: 87.4: 26.26		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369421 TIAR_HUMAN (268-360): 3.29e-14: 77.6: 29.03		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369064 TIA1_HUMAN (269-360): 1.23e-12: 73: 27.17		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		1119140 PAP1L_HUMAN (62-515): 2.4e-46: 178: 12.45		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1031409 PABP4_HUMAN (269-363): 1.28e-19: 96.2: 25.26		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269600 PABP3_HUMAN (265-363): 8.17e-17: 87.4: 26.26		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		963552 TIAR_HUMAN (268-360): 3.29e-14: 77.6: 29.03		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		680471 TIA1_HUMAN (269-360): 1.23e-12: 73: 27.17		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		782537 PABP4_HUMAN (269-363): 1.28e-19: 96.2: 25.26		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		611434 PABP4_HUMAN (269-363): 1.28e-19: 96.2: 25.26		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		516359 PABP1_HUMAN (265-363): 6.71e-19: 93.9: 25.25		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Mm
		509289 PABP1_MOUSE (265-363): 8.05e-19: 93.9: 25.25		RARA_MOUSE (81-545): 8.36e-104: 323: 22.37
+	Hs
		487081 PABP1_HUMAN (265-363): 6.71e-19: 93.9: 25.25		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16