HitPredict

Interactor 1: PER2 (O15055)
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
Gene: PER2

Interactor 2: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	23555304, 28514442, 33961781, 32296183, 34257372, 16790549, unassigned1304, 17218255
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, validated two hybrid, protein kinase assay, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032922 - circadian regulation of gene expression and 1 others more... GO:0042752 - regulation of circadian rhythm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 416
+	Hs
		165949 PER2_HUMAN (1-1255): 0: 569: 100.00		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		222713 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Mm
		222703 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		KC1A_MOUSE (2-326): 1.03e-134: 391: 69.54
+	Mm
		222711 PER2_MOUSE (1-1255): 2.02e-144: 472: 76.53		KC1D_MOUSE (1-406): 1.2e-125: 371: 83.50
+	Dm
		429417 PER_DROME (191-1159): 2.63e-139: 457: 16.94		KC1A_DROME (2-321): 9.31e-123: 361: 64.38
+	Dm
		283732 PER_DROME (191-1159): 2.63e-139: 457: 16.94		DCO_DROME (1-339): 2.92e-115: 345: 77.29
+	Mm
		1337560 BMAL1_MOUSE (20-577): 4.57e-113: 369: 17.19		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Hs
		126110 BMAL1_HUMAN (20-577): 1.21e-107: 354: 16.83		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		822275 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Hs
		681876 HIF1A_HUMAN (83-782): 1.15e-108: 363: 11.72		AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56
+	Hs
		182326 PER1_HUMAN (21-1234): 2.75e-86: 309: 38.90		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		830517 NCOA3_HUMAN (79-1203): 5.58e-86: 309: 11.13		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Mm
		193662 PER1_MOUSE (9-1230): 1.65e-84: 304: 39.10		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Mm
		193658 PER1_MOUSE (9-1230): 1.65e-84: 304: 39.10		KC1A_MOUSE (2-326): 1.03e-134: 391: 69.54
+	Hs
		830317 PER3_HUMAN (62-1218): 7.1e-78: 283: 32.39		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		182324 PER1_HUMAN (21-1234): 2.75e-86: 309: 38.90		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		193661 PER1_MOUSE (9-1230): 1.65e-84: 304: 39.10		KC1D_MOUSE (1-406): 1.2e-125: 371: 83.50
+	Hs
		181505 CLOCK_HUMAN (69-946): 2.54e-76: 273: 11.32		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		649042 ARNT_HUMAN (9-727): 5.1e-92: 316: 14.98		AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56
+	Hs
		182338 PER1_HUMAN (21-1234): 2.75e-86: 309: 38.90		KC1G2_HUMAN (3-348): 3.73e-119: 354: 50.28