HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005886 - plasma membrane GO:0014069 - postsynaptic density
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 740 Hs			1 817
+	Hs
		166629 DCLK1_HUMAN (1-740): 0: 896: 100.00		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Mm
		1164085 DCLK1_MOUSE (1-740): 0: 883: 96.43		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Hs
		1234196 DCLK2_HUMAN (1-725): 0: 801: 66.22		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		1234199 DCLK2_HUMAN (1-725): 0: 801: 66.22		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Hs
		166544 DCLK1_HUMAN (1-740): 0: 896: 100.00		AFAD_HUMAN (411-642): 8.91e-29: 126: 27.69
+	Hs
		166601 DCLK1_HUMAN (1-740): 0: 896: 100.00		MAGI1_HUMAN (462-688): 1.9e-10: 66.9: 10.48
+	Hs
		208290 DCX_HUMAN (6-345): 2.97e-136: 407: 72.13		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Mm
		292337 DCX_MOUSE (6-359): 2.77e-137: 410: 69.89		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Rn
		192513 KCC2D_RAT (385-738): 2.08e-129: 396: 32.96		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		1161534 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Rn
		192511 KCC2G_RAT (387-647): 1.29e-64: 225: 43.77		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Rn
		192510 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Hs
		1039101 KCC2D_HUMAN (385-737): 1.46e-130: 398: 33.05		RIMS1_HUMAN (126-637): 9e-45: 177: 17.41
+	Mm
		250629 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		LNX1_MOUSE (273-773): 1.71e-32: 137: 12.03
+	Mm
		292336 DCX_MOUSE (6-359): 2.77e-137: 410: 69.89		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Mm
		1143346 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		1021556 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		1050040 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Mm
		1143553 KS6A2_MOUSE (388-680): 2.2e-99: 324: 27.24		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Rn
		506740 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		DLG1_RAT (94-691): 8.42e-18: 90.6: 12.56