HitPredict

Interactor 1: CE290 (O15078)
Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2)
Gene: CEP290

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2479 Hs			1 669
+	Mm
		1112041 CE290_MOUSE (1-2451): 0: 628: 87.07		Q3TRF1_MOUSE (198-509): 3.68e-30: 124: 17.31
+	Hs
		166706 CE290_HUMAN (1-2479): 0: 650: 100.00		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		166727 CE290_HUMAN (1-2479): 0: 650: 100.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Mm
		139891 CE290_MOUSE (1-2451): 0: 628: 87.07		DCTN1_MOUSE (88-572): 4.8e-12: 71.6: 11.02
+	Hs
		1310111 CP250_HUMAN (1-954): 8.71e-29: 129: 9.40		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		969585 CENPE_HUMAN (6-1764): 5.52e-58: 225: 11.06		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Dm
		1229139 LVA_DROME (1048-2478): 5.15e-37: 156: 9.81		Q9VF13_DROME (158-659): 2.82e-29: 126: 13.87
+	Mm
		93578 PLEC_MOUSE (2-1228): 1.06e-38: 162: 9.59		DESP_MOUSE (337-641): 2.9e-11: 69.3: 18.65
+	Hs
		1068617 PLEC_HUMAN (1-1041): 3.75e-33: 144: 10.85		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		148769 GOGA4_HUMAN (1496-2478): 3.53e-35: 150: 10.79		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1068536 PLEC_HUMAN (1-1041): 3.75e-33: 144: 10.85		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		502933 MYH3_HUMAN (1092-2146): 4.13e-30: 133: 12.94		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		148841 PLEC_HUMAN (1-1041): 3.75e-33: 144: 10.85		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		522657 MYH7_HUMAN (1748-2477): 7.64e-28: 126: 13.78		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		502901 MYH3_HUMAN (1092-2146): 4.13e-30: 133: 12.94		MYH6_HUMAN (140-554): 2.32e-09: 63.1: 9.14
+	Hs
		1145917 CP250_HUMAN (1-954): 8.71e-29: 129: 9.40		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		528432 MYH8_HUMAN (1853-2477): 2.16e-24: 115: 9.15		MYH13_HUMAN (161-669): 3.57e-13: 75.4: 11.94
+	Hs
		528435 MYH8_HUMAN (1853-2477): 2.16e-24: 115: 9.15		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		522585 MYH7_HUMAN (1748-2477): 7.64e-28: 126: 13.78		MYH7_HUMAN (140-540): 9.01e-09: 61.2: 9.45
+	Hs
		1059229 GOGB1_HUMAN (3-911): 1.12e-25: 119: 13.23		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52