HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TBB4A (P04350)
Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)
Gene: TUBB4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 444
+	Hs
		167445 IKKA_HUMAN (1-745): 0: 588: 100.00		TBB5_HUMAN (1-429): 0: 714: 97.44
+	Hs
		158369 IKKB_HUMAN (1-743): 0: 583: 50.87		TBB5_HUMAN (1-429): 0: 714: 97.44
+	Hs
		158538 IKKB_HUMAN (1-743): 0: 583: 50.87		TBB2B_HUMAN (1-430): 0: 712: 96.74
+	Hs
		158364 IKKB_HUMAN (1-743): 0: 583: 50.87		TBB4A_HUMAN (1-427): 0: 709: 100.00
+	Hs
		428483 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TBB5_HUMAN (1-429): 0: 714: 97.44
+	Hs
		381323 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TBB4A_HUMAN (1-427): 0: 709: 100.00
+	Hs
		428204 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TBB5_HUMAN (1-429): 0: 714: 97.44
+	Hs
		381205 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TBB4A_HUMAN (1-427): 0: 709: 100.00
+	Hs
		625344 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		TBB4B_HUMAN (1-427): 0: 713: 98.60
+	Hs
		625420 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		TBB2A_HUMAN (1-430): 0: 709: 96.28
+	Hs
		1037424 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		TBB3_HUMAN (1-444): 0: 714: 91.44
+	Hs
		428478 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		TBB5_HUMAN (1-429): 0: 714: 97.44
+	Hs
		934009 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		TBB4B_HUMAN (1-427): 0: 713: 98.60
+	Hs
		1312829 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		TBB6_HUMAN (1-433): 0: 708: 93.07
+	Hs
		568654 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		TBB3_HUMAN (1-444): 0: 714: 91.44
+	Hs
		568659 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		TBB2A_HUMAN (1-430): 0: 709: 96.28
+	Dm
		445198 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		TBB3_DROME (1-443): 0: 700: 88.64
+	Dm
		1098170 IKKB_DROME (13-348): 6.83e-45: 174: 32.58		TBB1_DROME (1-429): 0: 711: 96.27
+	Dm
		902249 IKKB_DROME (13-348): 6.83e-45: 174: 32.58		TBB2_DROME (1-430): 0: 702: 94.88
+	Dm
		445208 IKKB_DROME (13-348): 6.83e-45: 174: 32.58		TBB3_DROME (1-443): 0: 700: 88.64