Protein: FBN2
Fibrillin-2 [Cleaved into: Placensin]

Gene: FBN2
Organism: Homo sapiens
Interactions: 78
UniProt ID: P35556

Gene Ontology (top 5):
GO:0001527 - microfibril
GO:0005179 - hormone activity
GO:0005201 - extracellular matrix structural constituent
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

772309

NOTC2
Neurogenic locus notch homolog protein 2

2

19

High-throughput

0.776

High

772272

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

2

19

Small-scale

0.768

High

772312

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

18

Small-scale

0.724

High

398001

KLKB1
Plasma kallikrein

1

13

High-throughput

0.691

High

772313

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

18

High-throughput

0.691

High

772316

FX4L6
Forkhead box protein D4-like 6

3

9

High-throughput

0.667

High

132999

MATN2
Matrilin-2

1

20

Small-scale

0.647

High

389095

FINC
Fibronectin

1

9

Small-scale

0.647

High

772302

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

18

Small-scale

0.647

High

772319

LYPD4
Ly6/PLAUR domain-containing protein 4

2

1

High-throughput

0.628

High

772326

ATL1
ADAMTS-like protein 1

2

13

High-throughput

0.628

High

772334

VWCE
von Willebrand factor C and EGF domain-containing protein

2

19

High-throughput

0.628

High

772351

PRG3
Proteoglycan 3

2

17

High-throughput

0.628

High

464423

TSP1
Thrombospondin-1

1

17

Small-scale

0.621

High

772353

ST14
Suppressor of tumorigenicity 14 protein

1

12

High-throughput

0.618

High

567807

PRG2
Bone marrow proteoglycan

2

17

High-throughput

0.611

High

772327

ZFP41
Zinc finger protein 41 homolog

3

20

High-throughput

0.609

High

772330

NET5
Netrin-5

2

20

High-throughput

0.601

High

439665

INSR
Insulin receptor

1

18

High-throughput

0.578

High

772346

EGFL7
Epidermal growth factor-like protein 7

1

19

High-throughput

0.575

High

772352

KLK5
Kallikrein-5

1

17

High-throughput

0.575

High

772323

TAFA3
Chemokine-like protein TAFA-3

2

3

High-throughput

0.574

High

772342

ZN408
Zinc finger protein 408

2

20

High-throughput

0.574

High

169982

AURKA
Aurora kinase A

2

3

High-throughput

0.558

High

772322

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

772349

FBX2
F-box only protein 2

2

20

High-throughput

0.549

High

144082

WNT7A
Protein Wnt-7a

1

20

High-throughput

0.536

High

405600

HRG
Histidine-rich glycoprotein

1

4

High-throughput

0.536

High

772310

MFAP5
Microfibrillar-associated protein 5

1

5

High-throughput

0.536

High

772325

DB125
Beta-defensin 125

1

1

High-throughput

0.536

High

772340

GREM2
Gremlin-2

1

4

High-throughput

0.536

High

584618

ELN
Elastin

1

9

Small-scale

0.501

High

772317

TRI68
E3 ubiquitin-protein ligase TRIM68

1

2

High-throughput

0.489

High

772320

IGFL3
Insulin growth factor-like family member 3

1

7

High-throughput

0.489

High

772339

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.489

High

772344

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.489

High

772345

ZN224
Zinc finger protein 224

1

10

High-throughput

0.489

High

590823

TIMP2
Metalloproteinase inhibitor 2

1

6

High-throughput

0.479

High

772307

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

772321

ATL5
ADAMTS-like protein 5

1

11

Small-scale

0.479

High

772315

ECM1
Extracellular matrix protein 1

1

1

Small-scale

0.457

High

289122

PRDM1
PR domain zinc finger protein 1

1

20

High-throughput

0.457

High

339671

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.457

High

464843

SP1
Transcription factor Sp1

1

20

High-throughput

0.457

High

772329

SP7
Transcription factor Sp7

1

20

High-throughput

0.457

High

167440

WNT9A
Protein Wnt-9a

1

20

High-throughput

0.445

High

772305

INHBE
Inhibin beta E chain

1

12

High-throughput

0.445

High

772324

LYPD1
Ly6/PLAUR domain-containing protein 1

1

2

High-throughput

0.445

High

772331

PATE1
Prostate and testis expressed protein 1

1

3

High-throughput

0.445

High

772332

EMID1
EMI domain-containing protein 1

1

10

High-throughput

0.445

High

772333

ESPB1
Epididymal sperm-binding protein 1

1

13

High-throughput

0.445

High

174490

TRI66
Tripartite motif-containing protein 66

1

10

High-throughput

0.437

High

217895

TGON2
Trans-Golgi network integral membrane protein 2

1

14

High-throughput

0.437

High

323207

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.437

High

342122

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

362877

EGFR
Epidermal growth factor receptor

1

18

High-throughput

0.437

High

566580

PDIA4
Protein disulfide-isomerase A4

1

12

High-throughput

0.437

High

693562

RL10
Large ribosomal subunit protein uL16

1

5

High-throughput

0.437

High

772304

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.437

High

772308

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

772311

CUL3
Cullin-3

1

16

High-throughput

0.437

High

772318

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.437

High

772335

ZDH15
Palmitoyltransferase ZDHHC15

1

4

Small-scale

0.437

High

772341

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.437

High

772343

FBX6
F-box only protein 6

1

20

High-throughput

0.437

High

772347

XPO7
Exportin-7

1

5

High-throughput

0.437

High

772348

HOOK1
Protein Hook homolog 1

1

4

High-throughput

0.437

High

772350

TRI33
E3 ubiquitin-protein ligase TRIM33

1

9

High-throughput

0.437

High

772306

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

1

Small-scale

0.417

High

772338

GFI1
Zinc finger protein Gfi-1

1

20

Small-scale

0.417

High

183596

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.407

High

772303

HD
Huntingtin

1

3

High-throughput

0.407

High

772314

ZNF74
Zinc finger protein 74

1

20

High-throughput

0.407

High

772336

FRMD6
FERM domain-containing protein 6

1

8

High-throughput

0.407

High

772337

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.407

High

772354

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.249

Low

772328

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025