HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 12707358, 15749833
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 3 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024