Protein: M3K20
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)

Gene: M3K20, MAP3K20
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9NYL2

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

927591

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.938

High

683762

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.903

High

905186

1433G
14-3-3 protein gamma

4

20

High-throughput

0.896

High

982554

1433F
14-3-3 protein eta

3

20

High-throughput

0.861

High

647328

1433T
14-3-3 protein theta

3

20

High-throughput

0.855

High

910094

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.820

High

1348570

M3K20
Mitogen-activated protein kinase kinase kinase 20

2

15

Small-scale

0.806

High

153182

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

17

Small-scale

0.789

High

684359

1433S
14-3-3 protein sigma

2

20

High-throughput

0.776

High

270452

KS6A5
Ribosomal protein S6 kinase alpha-5

1

5

High-throughput

0.756

High

1230633

ZN567
Zinc finger protein 567

6

3

High-throughput

0.738

High

1343994

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

4

5

High-throughput

0.698

High

1169144

ZFP2
Zinc finger protein ZFP2

4

4

High-throughput

0.698

High

587028

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.691

High

1342595

PAR6A
Partitioning defective 6 homolog alpha

1

3

High-throughput

0.691

High

1158955

ZFP1
Zinc finger protein 1 homolog

4

5

High-throughput

0.689

High

738586

TGFR1
TGF-beta receptor type-1

1

15

Small-scale

0.665

High

532331

ZNF35
Zinc finger protein 35

3

5

High-throughput

0.665

High

1078918

ITSN1
Intersectin-1

1

8

High-throughput

0.656

High

801004

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.647

High

854745

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

17

Small-scale

0.647

High

942992

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.647

High

1157054

ZN544
Zinc finger protein 544

2

3

High-throughput

0.628

High

1203690

ZN227
Zinc finger protein 227

2

1

High-throughput

0.621

High

160812

AURKA
Aurora kinase A

1

6

High-throughput

0.618

High

374989

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

19

High-throughput

0.618

High

1081976

PKN1
Serine/threonine-protein kinase N1

1

4

Small-scale

0.618

High

1147704

TENS3
Tensin-3

1

3

High-throughput

0.618

High

1172012

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.618

High

1343707

ANLN
Anillin

1

3

High-throughput

0.618

High

348074

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.611

High

1149833

ZN660
Zinc finger protein 660

2

5

High-throughput

0.606

High

958856

EM55
55 kDa erythrocyte membrane protein

1

3

High-throughput

0.587

High

370579

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

851175

CNN1
Calponin-1

1

1

High-throughput

0.553

High

988828

ZN33A
Zinc finger protein 33A

1

2

Small-scale

0.552

High

129988

MEIS1
Homeobox protein Meis1

1

3

High-throughput

0.536

High

154529

MEIS2
Homeobox protein Meis2

1

4

High-throughput

0.536

High

592537

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.536

High

649789

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

773092

PBX1
Pre-B-cell leukemia transcription factor 1

1

4

High-throughput

0.536

High

773145

PBX2
Pre-B-cell leukemia transcription factor 2

1

4

High-throughput

0.536

High

773211

PBX3
Pre-B-cell leukemia transcription factor 3

1

4

High-throughput

0.536

High

801431

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

887619

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.536

High

894512

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.536

High

1045714

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.536

High

1062693

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.536

High

1083022

CDC37
Hsp90 co-chaperone Cdc37

1

5

High-throughput

0.536

High

1260517

ZN296
Zinc finger protein 296

1

8

High-throughput

0.536

High

1261305

RN138
E3 ubiquitin-protein ligase RNF138

1

7

High-throughput

0.536

High

1263563

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1271111

EZH1
Histone-lysine N-methyltransferase EZH1

1

4

High-throughput

0.536

High

1319437

BC11B
B-cell lymphoma/leukemia 11B

1

5

High-throughput

0.536

High

1328476

BC11A
B-cell lymphoma/leukemia 11A

1

4

High-throughput

0.536

High

150397

ZN195
Zinc finger protein 195

1

0

High-throughput

0.513

High

308033

ZWINT
ZW10 interactor

1

0

High-throughput

0.513

High

579748

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

951913

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1310669

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

1080406

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.508

High

1119642

MIDN
Midnolin

1

1

High-throughput

0.508

High

1329099

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.508

High

1346317

RN19A
E3 ubiquitin-protein ligase RNF19A

1

1

High-throughput

0.508

High

1299653

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

9

High-throughput

0.501

High

1348572

SPCS1
Signal peptidase complex subunit 1

1

1

High-throughput

0.489

High

63149

CCD69
Coiled-coil domain-containing protein 69

1

0

High-throughput

0.486

High

131166

ZN593
Zinc finger protein 593

1

0

High-throughput

0.486

High

921448

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.486

High

1017246

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.486

High

1034206

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.486

High

1050905

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.486

High

1156405

ZN746
Zinc finger protein 746

1

0

High-throughput

0.486

High

125761

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

High-throughput

0.479

High

163383

XPO1
Exportin-1

1

1

High-throughput

0.479

High

387624

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

719195

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

959722

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1064205

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1269777

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1270474

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1285954

ZN775
Zinc finger protein 775

1

4

High-throughput

0.464

High

173397

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

0

High-throughput

0.458

High

893180

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

1241039

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

709084

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

354002

IGHM
Immunoglobulin heavy constant mu

1

4

High-throughput

0.417

High

650161

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

1023623

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1231422

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

1348571

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

326939

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024