HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: MYH10 (P35580)
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)
Gene: MYH10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1976
+	Hs
		158414 IKKB_HUMAN (1-743): 0: 583: 50.87		MYH10_HUMAN (1-1976): 0: 1106: 100.00
+	Hs
		725242 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH10_HUMAN (1-1976): 0: 1106: 100.00
+	Hs
		725161 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH10_HUMAN (1-1976): 0: 1106: 100.00
+	Hs
		625177 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH10_HUMAN (1-1976): 0: 1106: 100.00
+	Hs
		568568 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		MYH10_HUMAN (1-1976): 0: 1106: 100.00
+	Hs
		167488 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH11_HUMAN (805-1976): 1.82e-68: 259: 18.21
+	Hs
		167486 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95
+	Hs
		167573 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH14_HUMAN (889-1974): 4.36e-57: 221: 18.29
+	Hs
		728513 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH11_HUMAN (805-1976): 1.82e-68: 259: 18.21
+	Hs
		725010 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95
+	Hs
		724823 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95
+	Hs
		528401 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH8_HUMAN (930-1976): 2.91e-65: 248: 17.93
+	Hs
		1189798 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH14_HUMAN (889-1974): 4.36e-57: 221: 18.29
+	Hs
		625176 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95
+	Hs
		610795 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH2_HUMAN (930-1976): 4.58e-66: 251: 18.27
+	Hs
		522538 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH1_HUMAN (930-1976): 9.74e-66: 249: 18.26
+	Hs
		568567 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95
+	Hs
		610802 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH4_HUMAN (930-1976): 7.57e-64: 243: 17.51
+	Hs
		528359 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH6_HUMAN (986-1976): 1.7e-60: 232: 17.60
+	Hs
		724967 MARK4_HUMAN (13-224): 1.59e-24: 111: 34.56		MYH9_HUMAN (877-1976): 1.43e-64: 246: 17.95