Protein: CYTN
Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)

Gene: CYTN, CST1
Organism: Homo sapiens
Interactions: 144
UniProt ID: P01037

Gene Ontology (top 5):
GO:0001580 - detection of chemical stimulus involved in sensory perception of bitter taste
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0031982 - vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370051

CYTS
Cystatin-S

3

2

Small-scale

0.861

High

370138

CATL1
Procathepsin L

3

13

High-throughput

0.855

High

261579

CATL2
Cathepsin L2

2

13

High-throughput

0.811

High

370142

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

2

13

High-throughput

0.811

High

370218

UBTD2
Ubiquitin domain-containing protein 2

3

1

High-throughput

0.667

High

370238

GKN1
Gastrokine-1

2

1

High-throughput

0.628

High

370128

CYTN
Cystatin-SN

1

2

Small-scale

0.618

High

370227

LGMN
Legumain

1

3

Small-scale

0.618

High

292284

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

4

High-throughput

0.609

High

370184

TF2B
Transcription initiation factor IIB

3

2

High-throughput

0.609

High

370245

UBQL2
Ubiquilin-2

2

1

High-throughput

0.606

High

370243

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

2

0

High-throughput

0.602

High

370181

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.580

High

168948

QCR8
Cytochrome b-c1 complex subunit 8

2

1

High-throughput

0.574

High

318561

RHBT1
Rho-related BTB domain-containing protein 1

2

3

High-throughput

0.574

High

370180

RUXF
Small nuclear ribonucleoprotein F

2

2

High-throughput

0.574

High

370201

PKHG6
Pleckstrin homology domain-containing family G member 6

2

3

High-throughput

0.574

High

370216

FRMD1
FERM domain-containing protein 1

2

3

High-throughput

0.574

High

370236

DDX31
ATP-dependent DNA helicase DDX31

2

3

High-throughput

0.574

High

226654

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

1

High-throughput

0.573

High

370168

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

2

3

High-throughput

0.558

High

370217

KCNG4
Voltage-gated potassium channel regulatory subunit KCNG4

2

2

High-throughput

0.558

High

370223

HVCN1
Voltage-gated hydrogen channel 1

2

1

High-throughput

0.558

High

370237

TNR19
Tumor necrosis factor receptor superfamily member 19

2

2

Small-scale

0.558

High

134462

CCRL2
C-C chemokine receptor-like 2

1

4

High-throughput

0.536

High

167487

TX1B3
Tax1-binding protein 3

1

3

High-throughput

0.536

High

188635

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

High-throughput

0.536

High

370130

FRIH
Ferritin heavy chain

1

3

High-throughput

0.536

High

370136

CRF
Corticoliberin

1

2

High-throughput

0.536

High

370160

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.536

High

370173

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

1

High-throughput

0.536

High

370177

ARP3
Actin-related protein 3

1

1

High-throughput

0.536

High

370192

DAZ2
Deleted in azoospermia protein 2

1

2

High-throughput

0.536

High

370196

RCAN2
Calcipressin-2

1

5

High-throughput

0.536

High

370199

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

370207

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.536

High

370210

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

1

High-throughput

0.536

High

370214

COMD1
COMM domain-containing protein 1

1

2

High-throughput

0.536

High

370219

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

1

High-throughput

0.536

High

370221

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

370230

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.536

High

370235

GREM2
Gremlin-2

1

1

High-throughput

0.536

High

370247

NXT1
NTF2-related export protein 1

1

1

High-throughput

0.536

High

370195

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.513

High

370231

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

0

High-throughput

0.513

High

178882

SCAM2
Secretory carrier-associated membrane protein 2

1

2

High-throughput

0.489

High

284781

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.489

High

298278

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.489

High

370140

HBAT
Hemoglobin subunit theta-1

1

6

High-throughput

0.489

High

370179

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

3

High-throughput

0.489

High

370189

RING1
E3 ubiquitin-protein ligase RING1

1

1

High-throughput

0.489

High

370203

AKND1
Protein AKNAD1

1

2

High-throughput

0.489

High

370206

HBM
Hemoglobin subunit mu

1

6

High-throughput

0.489

High

370211

APLF
Aprataxin and PNK-like factor

1

1

High-throughput

0.489

High

370213

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.489

High

370215

CJ053
UPF0728 protein C10orf53

1

1

High-throughput

0.489

High

370220

RN141
RING finger protein 141

1

1

High-throughput

0.489

High

370222

CRGN
Gamma-crystallin N

1

2

High-throughput

0.489

High

370225

SNX27
Sorting nexin-27

1

2

High-throughput

0.489

High

370229

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.489

High

370240

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

4

High-throughput

0.489

High

370248

COR1C
Coronin-1C

1

2

High-throughput

0.489

High

186606

HMGB3
High mobility group protein B3

1

1

Small-scale

0.479

High

369988

TIMP1
Metalloproteinase inhibitor 1

1

2

Small-scale

0.479

High

370134

A4
Amyloid-beta precursor protein

1

6

Small-scale

0.479

High

370137

SAP
Prosaposin

1

1

Small-scale

0.479

High

370144

ANXA3
Annexin A3

1

1

Small-scale

0.479

High

370146

PDIA4
Protein disulfide-isomerase A4

1

2

Small-scale

0.479

High

370149

TIMP2
Metalloproteinase inhibitor 2

1

2

Small-scale

0.479

High

370153

FBLN1
Fibulin-1

1

6

Small-scale

0.479

High

370157

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

2

Small-scale

0.479

High

370175

PSA
Puromycin-sensitive aminopeptidase

1

1

Small-scale

0.479

High

370183

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

4

Small-scale

0.479

High

370190

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

370193

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

5

Small-scale

0.479

High

370194

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

370212

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

4

Small-scale

0.479

High

182069

PFD6
Prefoldin subunit 6

1

0

Small-scale

0.458

High

254013

CTND1
Catenin delta-1

1

0

Small-scale

0.458

High

276745

TBCA
Tubulin-specific chaperone A

1

0

Small-scale

0.458

High

370129

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.458

High

370131

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.458

High

370133

TYSY
Thymidylate synthase

1

0

Small-scale

0.458

High

370147

CD59
CD59 glycoprotein

1

0

Small-scale

0.458

High

370151

GSTM3
Glutathione S-transferase Mu 3

1

0

Small-scale

0.458

High

370156

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.458

High

370158

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

0

Small-scale

0.458

High

370159

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

Small-scale

0.458

High

370165

TALDO
Transaldolase

1

0

Small-scale

0.458

High

370166

MDHC
Malate dehydrogenase, cytoplasmic

1

0

Small-scale

0.458

High

370167

ACTY
Beta-centractin

1

0

Small-scale

0.458

High

370174

IF5
Eukaryotic translation initiation factor 5

1

0

Small-scale

0.458

High

370178

ARP2
Actin-related protein 2

1

0

Small-scale

0.458

High

370185

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

Small-scale

0.458

High

370205

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.458

High

370228

DNJC7
DnaJ homolog subfamily C member 7

1

0

Small-scale

0.458

High

370232

SH3L3
SH3 domain-binding glutamic acid-rich-like protein 3

1

0

Small-scale

0.458

High

370132

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.437

High

370135

INSR
Insulin receptor

1

4

Small-scale

0.437

High

370150

ITB5
Integrin beta-5

1

3

Small-scale

0.437

High

370155

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

4

Small-scale

0.437

High

370164

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

1

Small-scale

0.437

High

370188

UPAR
Urokinase plasminogen activator surface receptor

1

2

Small-scale

0.437

High

370198

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.437

High

370233

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

Small-scale

0.437

High

370246

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

6

Small-scale

0.437

High

370186

TAGL
Transgelin

1

0

High-throughput

0.426

High

370209

CPLX4
Complexin-4

2

0

High-throughput

0.328

High

370191

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.316

High

370249

IR3IP
Immediate early response 3-interacting protein 1

2

0

High-throughput

0.316

High

259279

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.279

Low

370141

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.279

Low

370169

OMP
Olfactory marker protein

1

0

High-throughput

0.279

Low

370176

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.279

Low

370200

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

370202

ATAT
Alpha-tubulin N-acetyltransferase 1

1

0

High-throughput

0.279

Low

370208

FBX42
F-box only protein 42

1

0

High-throughput

0.279

Low

370234

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.279

Low

70826

SYC1L
Synaptonemal complex central element protein 1-like

1

0

High-throughput

0.251

Low

184788

SPTC1
Serine palmitoyltransferase 1

1

0

Small-scale

0.249

Low

370139

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.249

Low

370143

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

Small-scale

0.249

Low

370145

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.249

Low

370148

CATE
Cathepsin E

1

0

Small-scale

0.249

Low

370152

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

Small-scale

0.249

Low

370154

TCEA1
Transcription elongation factor A protein 1

1

0

Small-scale

0.249

Low

370161

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

Small-scale

0.249

Low

370162

RFA3
Replication protein A 14 kDa subunit

1

0

Small-scale

0.249

Low

370170

RM19
Large ribosomal subunit protein bL19m

1

0

Small-scale

0.249

Low

370171

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

Small-scale

0.249

Low

370172

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

Small-scale

0.249

Low

370182

SERF2
Small EDRK-rich factor 2

1

0

Small-scale

0.249

Low

370187

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

0

Small-scale

0.249

Low

370197

SPCS2
Signal peptidase complex subunit 2

1

0

Small-scale

0.249

Low

370204

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

Small-scale

0.249

Low

370224

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.249

Low

370226

ATAD5
ATPase family AAA domain-containing protein 5

1

0

High-throughput

0.249

Low

370239

ABCF3
ATP-binding cassette sub-family F member 3

1

0

Small-scale

0.249

Low

370241

TECR
Very-long-chain enoyl-CoA reductase

1

0

Small-scale

0.249

Low

370242

MYOF
Myoferlin

1

0

Small-scale

0.249

Low

370244

TES
Testin

1

0

Small-scale

0.249

Low

282511

PAGE1
P antigen family member 1

1

0

High-throughput

0.232

Low

370163

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025