HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TTC3 (P53804)
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Gene: TTC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 2025
+	Hs
		1242059 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		RN214_HUMAN (1461-1998): 7.04e-101: 343: 20.90
+	Hs
		1123983 Q59GT1_HUMAN (1-702): 0: 550: 100.00		Q9BPW0_HUMAN (220-360): 5.96e-43: 167: 29.79
+	Hs
		1051339 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		DCTN1_HUMAN (1227-1708): 2.17e-62: 237: 13.50
+	Hs
		684793 Q59GT1_HUMAN (1-702): 0: 550: 100.00		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		297111 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TOM70_HUMAN (224-631): 8.39e-55: 205: 13.83
+	Hs
		858663 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		PPP5_HUMAN (220-360): 6.34e-43: 167: 29.79
+	Hs
		1123965 Q59GL9_HUMAN (67-512): 1.14e-131: 400: 56.98		Q9BPW0_HUMAN (220-360): 5.96e-43: 167: 29.79
+	Hs
		684792 Q59GL9_HUMAN (67-512): 1.14e-131: 400: 56.98		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		685087 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		684710 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		213543 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		SGTA_HUMAN (220-333): 1.13e-24: 108: 29.83
+	Zm
		2171 A0A0B4J305_MAIZE (6-509): 3.64e-124: 383: 17.92		A0A1D6KGT3_MAIZE (229-341): 1.49e-24: 107: 31.86
+	Hs
		174631 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24
+	Hs
		1305131 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23
+	Hs
		858650 ULK2_HUMAN (15-221): 2.42e-28: 124: 36.28		PPP5_HUMAN (220-360): 6.34e-43: 167: 29.79
+	Dm
		1359353 Q9V3Y8_DROME (7-355): 2.81e-31: 132: 27.62		Q9VH81_DROME (231-348): 2.45e-32: 136: 34.75
+	Dm
		1366325 Q9VGQ0_DROME (13-221): 2.35e-25: 113: 35.07		Q9VH81_DROME (231-348): 2.45e-32: 136: 34.75