Protein: SHAN2
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)

Gene: SHAN2, SHANK2
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q9UPX8

Gene Ontology (top 5):
GO:0001750 - photoreceptor outer segment
GO:0001917 - photoreceptor inner segment
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007416 - synapse assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121995

ARHG7
Rho guanine nucleotide exchange factor 7

2

17

Small-scale

0.815

High

1458348

NLK
Serine/threonine-protein kinase NLK

2

13

High-throughput

0.811

High

154404

DLGP1
Disks large-associated protein 1

2

20

Small-scale

0.800

High

1311227

RHG12
Rho GTPase-activating protein 12

2

10

High-throughput

0.783

High

1462613

BAIP2
BAR/IMD domain-containing adapter protein 2

2

20

High-throughput

0.783

High

1006123

DLG4
Disks large homolog 4

2

15

Small-scale

0.754

High

619135

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

High-throughput

0.747

High

1124758

SRC8
Src substrate cortactin

1

20

Small-scale

0.713

High

728482

AKT1
RAC-alpha serine/threonine-protein kinase

1

15

Small-scale

0.647

High

1460058

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

9

Small-scale

0.647

High

350669

DLGP3
Disks large-associated protein 3

1

20

Small-scale

0.621

High

1454133

DLGP2
Disks large-associated protein 2

1

20

Small-scale

0.621

High

1462614

DLGP4
Disks large-associated protein 4

1

20

Small-scale

0.621

High

364035

EGFR
Epidermal growth factor receptor

1

18

High-throughput

0.618

High

464081

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.618

High

557533

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

High-throughput

0.618

High

594141

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

699897

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

12

High-throughput

0.618

High

855809

CRK
Adapter molecule crk

1

18

High-throughput

0.618

High

988035

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1102384

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

1062415

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

7

High-throughput

0.606

High

1295230

HOME1
Homer protein homolog 1

2

20

High-throughput

0.606

High

896934

DYN2
Dynamin-2

1

8

Small-scale

0.573

High

397235

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1418525

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.527

High

173564

XPO1
Exportin-1

1

15

High-throughput

0.479

High

556428

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

615164

GBRG2
Gamma-aminobutyric acid receptor subunit gamma-2

1

2

High-throughput

0.479

High

991772

DYL1
Dynein light chain 1, cytoplasmic

1

3

Small-scale

0.479

High

1064397

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

3

Small-scale

0.479

High

1323385

GBRG1
Gamma-aminobutyric acid receptor subunit gamma-1

1

2

High-throughput

0.479

High

1390758

DYL2
Dynein light chain 2, cytoplasmic

1

3

Small-scale

0.479

High

1431445

EHD4
EH domain-containing protein 4

1

15

High-throughput

0.479

High

1462615

MYO5A
Unconventional myosin-Va

1

7

Small-scale

0.479

High

192883

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

373513

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.445

High

1233675

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

2

High-throughput

0.437

High

1367603

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1430005

SHRPN
Sharpin

1

4

Small-scale

0.408

High

1258618

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

1398220

RIPR3
RIPOR family member 3

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025