HitPredict

Interactor 1: TIF1A (O15164)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: TRIM24

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	34079125, 21531907
Identification Methods	proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0000791 - euchromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1050 Hs			1 183
+	Mm
		1145016 TIF1A_MOUSE (1-1050): 0: 587: 92.23		Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00
+	Hs
		170295 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Mm
		1143020 TIF1A_MOUSE (1-1050): 0: 587: 92.23		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Hs
		170331 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Mm
		949937 TIF1A_MOUSE (1-1050): 0: 587: 92.23		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Hs
		170481 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		1027331 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		949915 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		1335793 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Dm
		399034 Q9VDK5_DROME (9-1024): 2.35e-103: 352: 21.78		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Dm
		68987 A8WHL4_DROME (9-1024): 1.51e-103: 352: 21.22		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Hs
		1027278 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800532 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949891 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		1335787 TRIM1_HUMAN (31-471): 1.64e-70: 252: 14.95		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		203631 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		123298 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		123174 RO52_HUMAN (114-485): 2.09e-64: 227: 12.67		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		123187 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316043 LIN41_HUMAN (66-430): 5.44e-55: 208: 18.29		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78