Protein: OSBL6
Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)

Gene: OSBL6, OSBPL6
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9BZF3

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006699 - bile acid biosynthetic process
GO:0015485 - cholesterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

333179

VAPB
Vesicle-associated membrane protein-associated protein B/C

7

20

Small-scale

0.744

High

1419841

VAPA
Vesicle-associated membrane protein-associated protein A

5

20

High-throughput

0.720

High

920260

PLK1
Serine/threonine-protein kinase PLK1

4

5

High-throughput

0.694

High

1419828

OSBL7
Oxysterol-binding protein-related protein 7

1

12

High-throughput

0.691

High

1327839

ARRD1
Arrestin domain-containing protein 1

4

1

High-throughput

0.691

High

966841

1433G
14-3-3 protein gamma

3

20

High-throughput

0.667

High

1049748

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

170336

AURKA
Aurora kinase A

3

4

High-throughput

0.667

High

1419840

NOP53
Ribosome biogenesis protein NOP53

3

1

High-throughput

0.662

High

730214

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.650

High

990696

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

916194

BIEA
Biliverdin reductase A

3

0

High-throughput

0.638

High

50683

HACL2
2-hydroxyacyl-CoA lyase 2

2

2

High-throughput

0.628

High

1093948

TRAF1
TNF receptor-associated factor 1

2

1

High-throughput

0.628

High

1146626

TMED2
Transmembrane emp24 domain-containing protein 2

2

4

High-throughput

0.628

High

1395072

JPH4
Junctophilin-4

2

2

High-throughput

0.628

High

1419834

OSBL3
Oxysterol-binding protein-related protein 3

1

12

High-throughput

0.618

High

971967

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.611

High

628646

CAP7
Azurocidin

3

6

High-throughput

0.609

High

327432

ZFPL1
Zinc finger protein-like 1

3

3

High-throughput

0.604

High

652246

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

2

0

High-throughput

0.602

High

1415464

NUP58
Nucleoporin p58/p45

2

0

High-throughput

0.602

High

1419839

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.602

High

691398

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

1145352

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.601

High

226191

STX6
Syntaxin-6

1

2

High-throughput

0.536

High

1098937

KLRD1
Natural killer cells antigen CD94

1

3

High-throughput

0.536

High

1419835

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1419851

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

1394427

SHD
SH2 domain-containing adapter protein D

2

2

High-throughput

0.526

High

1163189

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.515

High

167389

KLF11
Krueppel-like factor 11

1

1

High-throughput

0.515

High

1325079

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.513

High

1413863

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1015300

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.489

High

1178084

RN151
RING finger protein 151

1

2

High-throughput

0.489

High

1325339

PHTF2
Protein PHTF2

1

1

High-throughput

0.489

High

1419847

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.489

High

208731

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

269609

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.479

High

279217

ULK1
Serine/threonine-protein kinase ULK1

1

6

Small-scale

0.479

High

281412

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

375914

RASK
GTPase KRas

1

13

High-throughput

0.479

High

941053

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

978275

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

986698

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1045733

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1065761

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

1219619

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1251431

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1293242

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.479

High

1309247

KSR1
Kinase suppressor of Ras 1

1

6

High-throughput

0.479

High

1352607

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.479

High

1419832

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

12

Small-scale

0.479

High

1419842

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.479

High

1419844

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.479

High

1419849

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1419850

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.479

High

252160

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

637949

NF1
Neurofibromin

1

0

High-throughput

0.458

High

719369

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

1216089

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.458

High

1410846

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1412875

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1419837

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1419843

CING
Cingulin

1

0

High-throughput

0.458

High

1419845

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

255200

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

337808

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.445

High

872017

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.445

High

902295

RB27A
Ras-related protein Rab-27A

1

8

High-throughput

0.445

High

1054142

BTK
Tyrosine-protein kinase BTK

1

2

High-throughput

0.445

High

1258566

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1346779

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

6

High-throughput

0.445

High

1352978

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

1419848

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.445

High

245271

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.437

High

589615

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

696428

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

769100

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1255416

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1419836

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.437

High

1419838

OTULL
Inactive ubiquitin thioesterase OTULINL

1

6

High-throughput

0.437

High

1148317

CNN3
Calponin-3

1

0

High-throughput

0.426

High

1131612

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.407

High

1394344

ZN414
Zinc finger protein 414

2

0

High-throughput

0.328

High

890259

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

1419846

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low

1394884

EAF1
ELL-associated factor 1

1

0

High-throughput

0.232

Low

1419833

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025