HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: TCPA (P17987)
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
Gene: TCP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	12502735, 23752268
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 556
+	Hs
		573251 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPA_HUMAN (1-556): 0: 630: 100.00
+	Hs
		573401 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPA_HUMAN (1-556): 0: 630: 100.00
+	Hs
		177233 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPG_HUMAN (5-550): 0: 593: 33.03
+	Hs
		826651 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPG_HUMAN (5-550): 0: 593: 33.03
+	Hs
		826803 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPG_HUMAN (5-550): 0: 593: 33.03
+	Hs
		177367 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPH_HUMAN (1-545): 0: 566: 34.84
+	Hs
		1038670 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPH_HUMAN (1-545): 0: 566: 34.84
+	Hs
		177231 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPE_HUMAN (4-530): 0: 550: 31.96
+	Hs
		821200 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPE_HUMAN (4-530): 0: 550: 31.96
+	Hs
		821342 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPE_HUMAN (4-530): 0: 550: 31.96
+	Sc
		519912 RPD3_YEAST (3-414): 0: 543: 57.07		TCPA_YEAST (4-542): 0: 558: 62.57
+	Sc
		693017 RPD3_YEAST (3-414): 0: 543: 57.07		TCPG_YEAST (1-538): 0: 552: 29.20
+	Sp
		140519 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPG_SCHPO (1-539): 0: 573: 30.44
+	Sp
		140556 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPA_SCHPO (2-542): 0: 564: 65.87
+	Sp
		140638 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPH_SCHPO (2-551): 0: 555: 36.32
+	Sc
		519976 HOS2_YEAST (4-420): 1.09e-174: 497: 50.36		TCPA_YEAST (4-542): 0: 558: 62.57
+	Sc
		760777 HOS2_YEAST (4-420): 1.09e-174: 497: 50.36		TCPG_YEAST (1-538): 0: 552: 29.20
+	Hs
		573514 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		TCPA_HUMAN (1-556): 0: 630: 100.00
+	Sc
		693035 RPD3_YEAST (3-414): 0: 543: 57.07		TCPH_YEAST (10-531): 1.74e-87: 282: 35.10
+	Sc
		792389 HOS2_YEAST (4-420): 1.09e-174: 497: 50.36		TCPH_YEAST (10-531): 1.74e-87: 282: 35.10