HitPredict

Interactor 1: IPO8 (O15397)
Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)
Gene: IPO8

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	27114554
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cse1~Ras, IBN_N~Ras
Common GO terms	GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1037 Hs			1 216
+	Hs
		312234 IPO7_HUMAN (1-1031): 0: 819: 64.57		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		874484 XPO2_HUMAN (2-1000): 4.14e-168: 520: 18.06		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698861 NMD5_YEAST (1-995): 3.39e-152: 481: 23.09		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Dm
		1373317 Q9VRV8_DROME (3-882): 6.12e-141: 447: 11.81		RANL_DROME (1-210): 2.56e-93: 273: 60.48
+	Hs
		919198 TNPO1_HUMAN (12-883): 1.02e-146: 462: 12.75		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		155560 TNPO2_HUMAN (12-883): 9.66e-136: 433: 12.21		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698750 CSE1_YEAST (2-980): 4.38e-131: 422: 15.85		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sc
		698917 KA120_YEAST (6-1000): 2.19e-129: 420: 14.06		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sp
		142272 CSE1_SCHPO (3-898): 8.22e-128: 414: 18.49		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	At
		784988 TNPO1_ARATH (3-858): 2.39e-118: 386: 13.13		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784992 IMB1_ARATH (1-819): 3.55e-118: 386: 13.40		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Sc
		698999 CSE1_YEAST (2-980): 4.38e-131: 422: 15.85		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Sc
		699016 KA120_YEAST (6-1000): 2.19e-129: 420: 14.06		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Sc
		698930 SXM1_YEAST (4-1000): 5.18e-125: 406: 20.45		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	At
		784999 IMB1_ARATH (1-819): 3.55e-118: 386: 13.40		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Hs
		919299 IPO11_HUMAN (1-996): 3.31e-122: 399: 16.09		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		1210454 IMB1_ARATH (1-819): 3.55e-118: 386: 13.40		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Hs
		919222 IPO9_HUMAN (4-994): 3.76e-119: 393: 14.41		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919077 IMB1_HUMAN (5-859): 6.55e-113: 371: 12.47		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698878 IMB5_YEAST (1-993): 7.83e-27: 120: 13.47		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56