HitPredict

Interactor 1: TOX3 (O15405)
TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein)
Gene: TOX3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 576 Hs			1 197
+	Mm
		653462 LEF1_MOUSE (48-348): 9.92e-33: 131: 11.22		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		980665 LEF1_HUMAN (49-348): 2.71e-33: 133: 11.56		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980642 SOX7_HUMAN (230-511): 3.71e-32: 129: 11.95		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817954 SOX2_HUMAN (219-467): 2.66e-30: 122: 11.07		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		818792 SOX9_HUMAN (170-369): 2.16e-28: 120: 16.82		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980859 SOX7_HUMAN (230-511): 3.71e-32: 129: 11.95		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		817955 SOX2_HUMAN (219-467): 2.66e-30: 122: 11.07		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		449690 HMGB1_HUMAN (249-369): 2.52e-17: 82.8: 20.33		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817967 SOX2_HUMAN (219-467): 2.66e-30: 122: 11.07		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		567682 UBF1_HUMAN (209-546): 1.19e-11: 69.8: 13.45		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		927926 HMGB1_MOUSE (249-369): 2.52e-17: 82.8: 20.33		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Hs
		980723 LEF1_HUMAN (49-348): 2.71e-33: 133: 11.56		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Hs
		449697 HMGB1_HUMAN (249-369): 2.52e-17: 82.8: 20.33		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		925827 HMGB1_MOUSE (249-369): 2.52e-17: 82.8: 20.33		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Dm
		558384 PANG2_DROME (79-485): 9.24e-38: 151: 9.20		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558368 PANG1_DROME (69-485): 1.15e-34: 141: 10.55		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558392 CIC_DROME (254-550): 8.43e-30: 127: 14.01		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558375 DICH_DROME (124-351): 1.54e-30: 125: 13.36		GROU_DROME (2-163): 3.54e-59: 198: 54.44