HitPredict

Interactor 1: CLOCK (O15516)
Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)
Gene: CLOCK

Interactor 2: CIPC (Q9C0C6)
CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)
Gene: CIPC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	23555304, 26186194, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 846 Hs			1 399
+	Mm
		139872 CLOCK_MOUSE (1-846): 3.46e-180: 542: 93.14		CIPC_MOUSE (1-399): 0: 644: 85.97
+	Hs
		126169 BMAL1_HUMAN (9-544): 1.35e-122: 385: 22.96		CIPC_HUMAN (1-399): 0: 674: 100.00
+	Hs
		1264409 BMAL2_HUMAN (12-528): 1.71e-116: 369: 22.71		CIPC_HUMAN (1-399): 0: 674: 100.00
+	Hs
		1306191 NPAS2_HUMAN (26-811): 8.02e-112: 362: 50.44		CIPC_HUMAN (1-399): 0: 674: 100.00