HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1255
+	Hs
		256843 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Mm
		222646 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		EGFR_MOUSE (17-1254): 0: 1126: 48.48
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		256853 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		181754 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		256842 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		256849 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Mm
		193352 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53
+	Rn
		102468 G3V6B4_RAT (1-211): 9.05e-50: 162: 88.21		JAK2_RAT (216-982): 1.86e-137: 450: 19.75
+	Hs
		181748 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Mm
		222647 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Mm
		193358 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42
+	Hs
		181850 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07
+	Hs
		181799 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47
+	Mm
		69806 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		B1ASP2_MOUSE (671-1035): 1.04e-42: 172: 19.47
+	Mm
		69808 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		B1ASP2_MOUSE (671-1035): 1.04e-42: 172: 19.47
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (357-634): 8.32e-17: 88.7: 19.54