HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 25814554, 29991678, unassigned1126
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~SH2, SH2~SOCS_box
Common GO terms GO:0005159 - insulin-like growth factor receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0019221 - cytokine-mediated signaling pathway
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 211
Hs

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Last updated: 15 Jul 2024