HitPredict

Interactor 1: CKS1 (O23249)
Cyclin-dependent kinases regulatory subunit 1 (CKS1-At)
Gene: CKS1

Interactor 2: CDKA1 (P24100)
Cyclin-dependent kinase A-1 (CDKA;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog A) (CDC2aAt)
Gene: CDKA-1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	9276444, 20706207, 25521792, 17426018, 20407024, 22098373, 11449057, 11432958
Identification Methods	pull down, affinity chromatography technology, two hybrid, protein complementation assay, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005737 - cytoplasm GO:0042023 - DNA endoreduplication
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 87 At			1 294
+	At
		621728 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00
+	Hs
		625283 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92
+	Hs
		895413 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03
+	At
		188137 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB11_ARATH (1-292): 4.04e-129: 371: 54.07
+	At
		188147 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB12_ARATH (1-292): 2.87e-129: 371: 54.69
+	At
		188156 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB21_ARATH (1-291): 3.62e-129: 371: 53.51
+	At
		188157 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB22_ARATH (1-292): 9.61e-129: 370: 54.00
+	At
		188163 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CDKD2_ARATH (1-293): 8.51e-127: 366: 48.81
+	Hs
		414843 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK1_HUMAN (1-292): 6.73e-138: 392: 66.55
+	At
		1103378 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB12_ARATH (1-292): 2.87e-129: 371: 54.69
+	At
		1227962 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB21_ARATH (1-291): 3.62e-129: 371: 53.51
+	At
		1321299 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKD1_ARATH (2-293): 8.54e-128: 371: 47.26
+	At
		639376 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB11_ARATH (1-292): 4.04e-129: 371: 54.07
+	At
		1228093 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB22_ARATH (1-292): 9.61e-129: 370: 54.00
+	Dm
		618415 Q9VHN1_DROME (2-71): 2.35e-37: 122: 70.00		CDK1_DROME (1-288): 3.84e-133: 380: 64.01
+	At
		1321252 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKD2_ARATH (1-293): 8.51e-127: 366: 48.81
+	Ce
		712291 CKS1_CAEEL (3-76): 2.05e-40: 129: 59.46		CDK1_CAEEL (1-291): 5.57e-129: 371: 56.86
+	At
		188168 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CDKD3_ARATH (2-293): 8.97e-120: 350: 47.95
+	Dm
		618471 Q9VHN1_DROME (2-71): 2.35e-37: 122: 70.00		CDK2_DROME (1-293): 8.12e-127: 365: 55.97
+	At
		1338686 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKD3_ARATH (2-293): 8.97e-120: 350: 47.95