Protein: NEK9
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)

Gene: NEK9
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q8TD19

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1350569

NEK6
Serine/threonine-protein kinase Nek6

8

19

Small-scale

0.974

High

1350542

NEK7
Serine/threonine-protein kinase Nek7

5

18

Small-scale

0.934

High

354742

PAK4
Serine/threonine-protein kinase PAK 4

2

16

High-throughput

0.811

High

163141

CHK1
Serine/threonine-protein kinase Chk1

2

12

Small-scale

0.789

High

991646

DYL1
Dynein light chain 1, cytoplasmic

8

6

High-throughput

0.752

High

981602

RAN
GTP-binding nuclear protein Ran

1

8

Small-scale

0.724

High

1350550

DYL2
Dynein light chain 2, cytoplasmic

5

6

High-throughput

0.712

High

920132

PLK1
Serine/threonine-protein kinase PLK1

1

16

Small-scale

0.700

High

259006

DNJA2
DnaJ homolog subfamily A member 2

1

6

High-throughput

0.691

High

1147973

SF3B3
Splicing factor 3B subunit 3

1

4

High-throughput

0.691

High

468630

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

1350544

TITIN
Titin

1

0

High-throughput

0.663

High

328080

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

19

Small-scale

0.649

High

508320

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.647

High

1286368

NEK8
Serine/threonine-protein kinase Nek8

1

19

Small-scale

0.647

High

952256

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

19

High-throughput

0.646

High

1350563

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

3

19

Small-scale

0.641

High

1350577

MAFF
Transcription factor MafF

3

0

High-throughput

0.638

High

1350560

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

19

Small-scale

0.636

High

1350379

BICD2
Protein bicaudal D homolog 2

2

20

Small-scale

0.634

High

1252071

RN19B
E3 ubiquitin-protein ligase RNF19B

2

11

High-throughput

0.628

High

170247

AURKA
Aurora kinase A

1

16

High-throughput

0.618

High

242370

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.618

High

412303

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

461743

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

831105

CCNF
Cyclin-F

1

9

High-throughput

0.618

High

995711

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.618

High

1107042

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.618

High

372652

MYC
Myc proto-oncogene protein

2

14

High-throughput

0.611

High

1350559

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

7

High-throughput

0.611

High

1350568

EMAL4
Echinoderm microtubule-associated protein-like 4

2

9

Small-scale

0.611

High

1065314

SSRP1
FACT complex subunit SSRP1

2

1

Small-scale

0.601

High

1350567

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

0

Small-scale

0.593

High

1350562

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

19

High-throughput

0.586

High

862318

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

1209427

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.575

High

1350541

NEK9
Serine/threonine-protein kinase Nek9

1

18

High-throughput

0.575

High

967869

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

14

High-throughput

0.571

High

1181486

EMAL3
Echinoderm microtubule-associated protein-like 3

2

12

High-throughput

0.571

High

1350564

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.553

High

134954

EMAL1
Echinoderm microtubule-associated protein-like 1

1

9

High-throughput

0.536

High

542586

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

1130115

SMC1A
Structural maintenance of chromosomes protein 1A

1

16

High-throughput

0.536

High

1310260

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1350546

FAN
Protein FAN

1

6

High-throughput

0.536

High

1350548

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1350556

TBA1C
Tubulin alpha-1C chain

1

17

High-throughput

0.536

High

1350565

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1350570

E41L5
Band 4.1-like protein 5

1

9

High-throughput

0.536

High

1350572

PRD11
PR domain-containing protein 11

1

2

High-throughput

0.536

High

1350557

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

19

High-throughput

0.527

High

595530

H15
Histone H1.5

1

2

High-throughput

0.515

High

347828

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.513

High

1207242

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1350558

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

173117

XPO1
Exportin-1

1

19

High-throughput

0.479

High

228917

CF410
Cilia- and flagella-associated protein 410

1

4

High-throughput

0.479

High

246800

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

414271

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

520217

ANDR
Androgen receptor

1

15

High-throughput

0.479

High

521825

H14
Histone H1.4

1

2

High-throughput

0.479

High

589232

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696015

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

730785

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731491

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.479

High

768714

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

970819

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

971810

1433E
14-3-3 protein epsilon

1

19

High-throughput

0.479

High

1028301

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.479

High

1067529

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1109924

HDAC1
Histone deacetylase 1

1

9

High-throughput

0.479

High

1113790

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1114951

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

1138423

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1197031

AMOT
Angiomotin

1

19

High-throughput

0.479

High

1276522

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1280355

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

18

High-throughput

0.479

High

1289476

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1350543

NUDC2
NudC domain-containing protein 2

1

5

High-throughput

0.479

High

1350545

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1350554

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1350561

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1350566

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

1350575

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1350576

RCOR1
REST corepressor 1

1

4

High-throughput

0.479

High

1350547

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.458

High

1350553

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1350571

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

437499

CASB
Beta-casein

1

2

Small-scale

0.457

High

1311635

KIBRA
Protein KIBRA

1

16

High-throughput

0.445

High

218521

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

838501

GRIA2
Glutamate receptor 2

1

2

High-throughput

0.437

High

1121054

BOP1
Ribosome biogenesis protein BOP1

1

3

High-throughput

0.437

High

1238355

RETST
All-trans-retinol 13,14-reductase

1

4

High-throughput

0.437

High

1243829

CTR9
RNA polymerase-associated protein CTR9 homolog

1

7

High-throughput

0.437

High

1350549

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

1350574

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

7

High-throughput

0.437

High

1092600

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

409460

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.407

High

1253636

PKHG7
Pleckstrin homology domain-containing family G member 7

1

10

High-throughput

0.407

High

1316912

FAM9C
Protein FAM9C

1

1

High-throughput

0.407

High

1350551

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.407

High

1350555

KXDL1
KxDL motif-containing protein 1

2

0

High-throughput

0.313

High

570701

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

1179823

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1328462

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

1350552

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1033394

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.249

Low

1179663

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.249

Low

1350573

FAME
Factor associated with metabolism and energy

1

0

High-throughput

0.249

Low

67173

ZAR1L
Protein ZAR1-like

1

0

High-throughput

0.232

Low

576125

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025