Protein: RCC2
Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)

Gene: RCC2
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9P258

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005730 - nucleolus
GO:0005829 - cytosol
GO:0005874 - microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

243170

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

981150

H2B1C
Histone H2B type 1-C/E/F/G/I

2

4

High-throughput

0.584

High

1067784

EP300
Histone acetyltransferase p300

2

7

High-throughput

0.584

High

354791

PAK4
Serine/threonine-protein kinase PAK 4

2

1

Small-scale

0.571

High

397111

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1327805

SH2D3
SH2 domain-containing protein 3C

2

6

High-throughput

0.571

High

1391062

OTUB1
Ubiquitin thioesterase OTUB1

2

2

High-throughput

0.571

High

540959

ERG
Transcriptional regulator ERG

1

2

Small-scale

0.561

High

1454298

COR1C
Coronin-1C

1

4

Small-scale

0.561

High

166201

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

389548

FINC
Fibronectin

1

3

High-throughput

0.536

High

572855

NCF1
Neutrophil cytosol factor 1

1

1

High-throughput

0.536

High

613478

VINC
Vinculin

1

2

High-throughput

0.536

High

639319

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

High-throughput

0.536

High

765955

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.536

High

908472

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.536

High

1150574

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

High-throughput

0.536

High

1161724

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.536

High

1433617

DEFI6
Differentially expressed in FDCP 6 homolog

1

5

High-throughput

0.536

High

831564

CCNF
Cyclin-F

1

8

High-throughput

0.515

High

1454301

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

280852

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.501

High

951883

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

1371748

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.501

High

1295640

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.489

High

1436813

WDR76
WD repeat-containing protein 76

1

11

High-throughput

0.489

High

125645

LEG9
Galectin-9

1

2

High-throughput

0.479

High

132354

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

260558

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

272515

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.479

High

318896

RHBT1
Rho-related BTB domain-containing protein 1

1

7

High-throughput

0.479

High

320108

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

346431

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

363954

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

373363

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

380175

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

4

High-throughput

0.479

High

406750

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

412726

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

414753

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

447527

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

473149

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

520413

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

539849

RALA
Ras-related protein Ral-A

1

1

Small-scale

0.479

High

616372

RCC1
Regulator of chromosome condensation

1

13

High-throughput

0.479

High

625677

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.479

High

631001

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

643112

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

685755

U2AF2
Splicing factor U2AF 65 kDa subunit

1

9

High-throughput

0.479

High

731658

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

767361

MERL
Merlin

1

2

High-throughput

0.479

High

791791

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

822891

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.479

High

863010

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

Small-scale

0.479

High

888362

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

891841

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

905226

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

907609

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.479

High

941075

HDAC4
Histone deacetylase 4

1

9

High-throughput

0.479

High

955703

CDC42
Cell division control protein 42 homolog

1

4

Small-scale

0.479

High

971218

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.479

High

975289

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

980461

H4
Histone H4

1

1

High-throughput

0.479

High

981722

RAN
GTP-binding nuclear protein Ran

1

7

High-throughput

0.479

High

988784

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

Small-scale

0.479

High

995863

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

998077

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.479

High

1091167

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.479

High

1094995

TRAF3
TNF receptor-associated factor 3

1

5

Small-scale

0.479

High

1101069

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1103421

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

1107290

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1115469

CUL4B
Cullin-4B

1

15

High-throughput

0.479

High

1135144

CUL7
Cullin-7

1

6

High-throughput

0.479

High

1138128

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

1138708

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1206380

DOC11
Dedicator of cytokinesis protein 11

1

2

Small-scale

0.479

High

1215876

RC3H1
Roquin-1

1

2

High-throughput

0.479

High

1289673

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1290785

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.479

High

1313489

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1326451

MINK1
Misshapen-like kinase 1

1

5

High-throughput

0.479

High

1335018

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1337846

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

1339010

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

1340825

COP1
E3 ubiquitin-protein ligase COP1

1

14

High-throughput

0.479

High

1347883

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

1364286

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1364638

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1370423

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.479

High

1387611

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1391819

AURKB
Aurora kinase B

1

5

Small-scale

0.479

High

1393779

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1397507

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1405692

NECD
Necdin

1

3

High-throughput

0.479

High

1411741

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1420372

TRI31
E3 ubiquitin-protein ligase TRIM31

1

7

High-throughput

0.479

High

1420975

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

High-throughput

0.479

High

1430083

RGAP1
Rac GTPase-activating protein 1

1

5

Small-scale

0.479

High

1430610

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1431330

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

1433098

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1434103

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1436522

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1446406

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

1447378

ANLN
Anillin

1

2

High-throughput

0.479

High

1448219

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1451295

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1451388

PK1IP
p21-activated protein kinase-interacting protein 1

1

11

Small-scale

0.479

High

1453775

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

1454291

MBD5
Methyl-CpG-binding domain protein 5

1

3

High-throughput

0.479

High

1454293

HDAC6
Protein deacetylase HDAC6

1

9

High-throughput

0.479

High

1454295

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1454296

TNIK
TRAF2 and NCK-interacting protein kinase

1

5

High-throughput

0.479

High

1454299

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

1454300

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

1454303

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

1454304

TRAF6
TNF receptor-associated factor 6

1

5

High-throughput

0.479

High

365484

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

378198

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

659848

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

668054

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

867474

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

941289

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

945111

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.458

High

960595

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

1126198

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

1200157

BOREA
Borealin

1

0

Small-scale

0.458

High

1241821

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1454294

TRM7
tRNA

1

0

High-throughput

0.458

High

1417852

RNF26
E3 ubiquitin-protein ligase RNF26

1

3

Small-scale

0.457

High

430450

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

530489

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

619944

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.445

High

935217

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

944090

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

987993

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.445

High

1130498

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

1292297

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

1420744

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1430352

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

14

High-throughput

0.445

High

1433222

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

14

High-throughput

0.445

High

1437384

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

248122

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

294458

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

316099

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.437

High

474339

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

589909

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

607174

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

696729

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

769384

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

832583

ETV3
ETS translocation variant 3

1

2

High-throughput

0.437

High

965294

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

998892

H31
Histone H3.1

1

7

High-throughput

0.437

High

1017262

H33
Histone H3.3

1

7

High-throughput

0.437

High

1087696

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

6

High-throughput

0.437

High

1133703

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.437

High

1162064

H31T
Histone H3.1t

1

7

High-throughput

0.437

High

1229404

DUS29
Dual specificity phosphatase 29

1

2

High-throughput

0.437

High

1255891

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1260629

ASXL2
Putative Polycomb group protein ASXL2

1

6

High-throughput

0.437

High

1312434

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

1314458

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.437

High

1327239

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.437

High

1332721

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.437

High

1367462

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1387344

OTUB2
Ubiquitin thioesterase OTUB2

1

2

Small-scale

0.437

High

1387743

MBD6
Methyl-CpG-binding domain protein 6

1

5

High-throughput

0.437

High

1401421

CIC
Protein capicua homolog

1

4

High-throughput

0.437

High

1421199

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.437

High

1433460

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

1452381

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

1454292

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

High-throughput

0.437

High

1454297

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1146

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

564483

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1395549

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

1434562

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

887283

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

403023

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

1013348

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1392774

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1403178

INT14
Integrator complex subunit 14

1

0

High-throughput

0.279

Low

194374

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

257514

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

1205498

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1357586

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1415891

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

1449234

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

1454302

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1454305

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.249

Low

1047335

P
P protein

1

0

High-throughput

0.232

Low

1253209

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1337008

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.232

Low

1430992

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025