HitPredict

Interactor 1: FOXP2 (O15409)
Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein)
Gene: FOXP2

Interactor 2: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.731

Property	Details
Experiments	14701752, 21653829, 25416956, 27107012, 24722188
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, barcode fusion genetics two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001221 - transcription coregulator binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 715 Hs			1 440
+	Hs
		190053 FOXP2_HUMAN (1-715): 8.77e-174: 516: 100.00		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		1103371 FOXP1_HUMAN (1-715): 1.95e-151: 457: 61.02		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		941553 FOXP1_HUMAN (1-715): 1.95e-151: 457: 61.02		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		1029673 FOXK2_HUMAN (395-695): 2.03e-54: 200: 22.43		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		1017413 FOXK1_HUMAN (388-696): 5.99e-51: 191: 20.67		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		941472 FOXI2_HUMAN (407-687): 1.03e-52: 186: 18.31		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		133104 FOXE1_HUMAN (457-692): 1.1e-50: 182: 20.88		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		1091096 FOXC1_HUMAN (465-580): 8.38e-43: 165: 34.43		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		221929 FOXS1_HUMAN (484-707): 7.37e-46: 168: 21.10		CTBP2_HUMAN (10-439): 0: 538: 80.23