HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	19385048, 18590740, 15601820
Identification Methods	pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 780
+	Hs
		147440 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193366 SOCS2_MOUSE (3-221): 1.44e-48: 159: 28.31		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146642 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		147544 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1322060 SOCS6_MOUSE (8-220): 4.11e-43: 153: 23.39		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1143676 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1265273 SOCS4_MOUSE (16-221): 3.32e-42: 149: 20.29		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1263831 SOCS4_HUMAN (16-221): 4.62e-42: 149: 19.81		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		1274062 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		222648 SOCS5_MOUSE (23-221): 3.46e-39: 143: 21.00		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		256856 SOCS5_HUMAN (23-221): 1.3e-39: 144: 21.00		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1257617 SOCS7_MOUSE (16-221): 2.42e-38: 141: 25.24		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146692 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		181885 SOCS1_HUMAN (17-221): 1.61e-40: 139: 27.89		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		147421 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		1042817 VAV3_HUMAN (17-207): 9.71e-41: 149: 14.14		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		146625 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		855795 VAV2_HUMAN (13-205): 3.23e-39: 145: 13.92		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		1041477 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Hs
		181856 SOCS1_HUMAN (17-221): 1.61e-40: 139: 27.89		CUL2_HUMAN (10-780): 0: 688: 26.37