HitPredict

Interactor 1: WIPF1 (O43516)
WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
Gene: WIPF1

Interactor 2: HCLS1 (P14317)
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Gene: HCLS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21398607
Identification Methods	pull down, far western blotting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Hs			1 486
+	Hs
		206687 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86
+	Hs
		1052345 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86
+	Mm
		1141099 WIPF1_MOUSE (14-503): 4.22e-26: 112: 85.13		SRC8_MOUSE (1-486): 5.07e-128: 384: 40.88
+	Hs
		581076 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		PLCG1_HUMAN (55-485): 1.1e-40: 158: 17.41
+	Hs
		992476 SOS1_HUMAN (134-459): 8.01e-24: 107: 16.77		SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41
+	Mm
		1143290 SOS1_MOUSE (134-459): 4.5e-23: 105: 21.47		PLCG1_MOUSE (55-485): 1.11e-42: 164: 18.30
+	Hs
		580987 SOS1_HUMAN (134-459): 8.01e-24: 107: 16.77		PLCG1_HUMAN (55-485): 1.1e-40: 158: 17.41
+	Hs
		206694 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		PACN1_HUMAN (138-485): 3.98e-34: 135: 15.01
+	Hs
		1316001 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		PACN1_HUMAN (138-485): 3.98e-34: 135: 15.01
+	Hs
		596214 SOS1_HUMAN (134-459): 8.01e-24: 107: 16.77		NEBU_HUMAN (145-485): 2.9e-35: 142: 16.03
+	Hs
		1307440 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		SH3G2_HUMAN (180-485): 1.31e-31: 126: 15.74
+	Hs
		992493 SOS1_HUMAN (134-459): 8.01e-24: 107: 16.77		PACN1_HUMAN (138-485): 3.98e-34: 135: 15.01
+	Rn
		88907 D4A3T0_RAT (134-459): 1.58e-23: 106: 19.94		PACN1_RAT (138-485): 2.49e-34: 135: 15.82
+	Hs
		978569 PRB3_HUMAN (235-497): 3.46e-16: 81.8: 17.49		SH3G1_HUMAN (242-485): 1.26e-31: 126: 19.26
+	Hs
		206698 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		ABI2_HUMAN (269-485): 3.95e-14: 76.5: 22.22
+	Hs
		1270628 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		STAM1_HUMAN (358-482): 2e-13: 74.5: 21.60
+	Ce
		70017 G5EBN5_CAEEL (64-481): 3.46e-11: 68.2: 15.77		SH3GH_CAEEL (241-485): 1.57e-29: 121: 14.69
+	Hs
		166049 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		ITSN1_HUMAN (339-485): 3.14e-11: 68.1: 20.25
+	Hs
		235556 WIPF2_HUMAN (10-503): 6.61e-24: 105: 32.60		VINEX_HUMAN (344-485): 6.67e-14: 76.2: 18.75
+	Hs
		992477 SOS1_HUMAN (134-459): 8.01e-24: 107: 16.77		ITSN1_HUMAN (339-485): 3.14e-11: 68.1: 20.25