HitPredict

Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.60 0.655

The method score is based on:

Property Details
Experiments 16938345, 14523017
Identification Methods enzymatic study, affinity chromatography technology, protein kinase assay, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001772 - immunological synapse
GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
GO:0035556 - intracellular signal transduction
GO:0045121 - membrane raft
and 1 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 262
Hs

1 509
+ Hs
+ Hs
+ Mm
+ Mm

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Last updated: 15 Jul 2024