HitPredict

Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 0.60 0.629

The method score is based on:

Property Details
Experiments 27221712, 24642916
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0019722 - calcium-mediated signaling
GO:0019901 - protein kinase binding
GO:0035556 - intracellular signal transduction
GO:0045121 - membrane raft
and 1 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 262
Hs

1 1265
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024