HitPredict

Interactor 1: RGS14 (O43566)
Regulator of G-protein signaling 14 (RGS14)
Gene: RGS14

Interactor 2: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11387333
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~GoLoco, G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway and 2 others more... GO:0030425 - dendrite GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 566 Hs			1 355
+	Hs
		207517 RGS14_HUMAN (1-566): 0: 656: 100.00		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		207507 RGS14_HUMAN (1-566): 0: 656: 100.00		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		207511 RGS14_HUMAN (1-566): 0: 656: 100.00		GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42
+	Mm
		579646 RGS14_MOUSE (1-545): 0: 594: 87.93		GNAO_MOUSE (1-355): 1.69e-171: 482: 68.45
+	Hs
		158597 RGS12_HUMAN (3-562): 7.98e-167: 513: 36.61		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		158608 RGS12_HUMAN (3-562): 7.98e-167: 513: 36.61		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		158599 RGS12_HUMAN (3-562): 7.98e-167: 513: 36.61		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Dm
		558483 RGS_DROME (7-514): 7.23e-131: 418: 28.41		GNAO_DROME (1-355): 9.4e-166: 468: 67.89
+	Dm
		592744 RGS_DROME (7-514): 7.23e-131: 418: 28.41		GNAI_DROME (1-355): 1.12e-163: 463: 76.40
+	Hs
		170629 AXIN1_HUMAN (1-494): 2.48e-147: 447: 18.60		GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83
+	Hs
		444693 RGS7_HUMAN (6-199): 9.43e-65: 221: 27.04		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		391473 RGS18_HUMAN (51-216): 1.23e-61: 205: 31.74		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		180650 RGS16_HUMAN (8-183): 4.71e-62: 204: 33.33		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		277782 RGS9_HUMAN (28-212): 1.28e-62: 219: 30.65		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		926720 RGS18_HUMAN (51-216): 1.23e-61: 205: 31.74		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		444800 RGS18_HUMAN (51-216): 1.23e-61: 205: 31.74		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Bt
		221230 RGS9_BOVIN (28-212): 4.67e-66: 224: 31.18		GNAT1_BOVIN (1-355): 6.59e-165: 465: 65.92
+	Hs
		834946 RGS7_HUMAN (6-199): 9.43e-65: 221: 27.04		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		580410 RGS7_HUMAN (6-199): 9.43e-65: 221: 27.04		GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38
+	Hs
		837653 RGS18_HUMAN (51-216): 1.23e-61: 205: 31.74		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42