HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 508
+	Hs
		208349 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		973639 SPY4_HUMAN (4-305): 6.69e-92: 277: 40.78		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		208417 SPY3_HUMAN (39-305): 3.2e-89: 269: 44.89		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		973600 SPRE1_HUMAN (142-277): 3.35e-39: 145: 25.18		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00