HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1342
+	Hs
		557604 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		209056 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		208972 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383587 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		208970 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337883 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337337 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		208976 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Mm
		337637 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		ABL1_MOUSE (696-1296): 5.65e-125: 417: 22.21
+	Mm
		222878 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		208996 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		209018 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		435526 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		209039 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		209001 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		209000 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TXK_HUMAN (707-969): 2.69e-44: 171: 37.12
+	Hs
		209036 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		557630 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Rn
		88904 D4A3M8_RAT (1-380): 3.21e-98: 298: 95.79		INSR_RAT (329-650): 1.42e-20: 101: 16.71