Protein: SC6B1
Protein transport protein SBH1 (Sec61 complex subunit SBH1) (Sec61 complex subunit beta)

Gene: SC6B1, SBH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: P52870

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005783 - endoplasmic reticulum
GO:0005784 - Sec61 translocon complex
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

748466

SC61A
Protein transport protein SEC61

9

3

Small-scale

0.966

High

763160

SC61G
Protein transport protein SSS1

6

1

Small-scale

0.929

High

798655

SSH1
Sec sixty-one protein homolog

2

3

Small-scale

0.744

High

754644

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

3

1

Small-scale

0.667

High

914911

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4

3

1

Small-scale

0.667

High

873141

OST3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3

2

2

Small-scale

0.640

High

863318

OST2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2

2

1

Small-scale

0.629

High

809025

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

2

1

Small-scale

0.619

High

524563

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.595

High

545563

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

Small-scale

0.586

High

797001

PHO88
SRP-independent targeting protein 3

2

1

Small-scale

0.586

High

835059

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

Small-scale

0.586

High

914901

SPC2
Signal peptidase complex subunit 2

2

1

Small-scale

0.586

High

914900

RTN1
Reticulon-like protein 1

2

1

Small-scale

0.584

High

914905

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

2

0

Small-scale

0.577

High

914906

GET3
ATPase GET3

2

0

Small-scale

0.577

High

641386

SEC62
Translocation protein SEC62

2

0

Small-scale

0.576

High

914908

YOP1
Protein YOP1

2

0

Small-scale

0.561

High

577179

SEC63
Protein translocation protein SEC63

2

1

Small-scale

0.552

High

754408

SEC66
Translocation protein SEC66

1

0

Small-scale

0.546

High

914904

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

2

High-throughput

0.541

High

797607

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.518

High

903531

PDR10
ATP-dependent permease PDR10

1

2

High-throughput

0.494

High

527180

HSP72
Heat shock protein SSA2

1

1

Small-scale

0.481

High

672163

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.481

High

737161

ERG24
Delta(14)-sterol reductase ERG24

1

1

Small-scale

0.481

High

822261

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

1

Small-scale

0.481

High

914899

OST6
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6

1

2

Small-scale

0.481

High

914907

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

1

Small-scale

0.481

High

863330

SPC1
Signal peptidase complex subunit 1

1

1

Small-scale

0.479

High

914909

RTN2
Reticulon-like protein 2

1

1

Small-scale

0.479

High

914912

ENV10
SRP-independent targeting protein 2

1

1

High-throughput

0.479

High

365659

PGK
Phosphoglycerate kinase

1

0

Small-scale

0.460

High

376236

RAS2
Ras-like protein 2

1

0

Small-scale

0.460

High

394724

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.460

High

416263

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.460

High

481907

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.460

High

509644

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.460

High

548785

MCM1
Pheromone receptor transcription factor

1

0

Small-scale

0.460

High

679875

CDC48
Cell division control protein 48

1

0

Small-scale

0.460

High

734808

VPH2
Vacuolar ATPase assembly integral membrane protein VPH2

1

0

Small-scale

0.460

High

792144

GBLP
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.460

High

794938

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.460

High

805799

NSG1
Protein NSG1

1

0

Small-scale

0.460

High

818179

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

Small-scale

0.460

High

827041

MGA2
Protein MGA2

1

0

High-throughput

0.460

High

827084

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.460

High

849504

CWP2
Cell wall protein CWP2

1

0

Small-scale

0.460

High

858107

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.460

High

914893

GUP1
Membrane-bound O-acyltransferase GUP1

1

0

Small-scale

0.460

High

914894

PROA
Gamma-glutamyl phosphate reductase

1

0

Small-scale

0.460

High

914895

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

Small-scale

0.460

High

914896

PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

Small-scale

0.460

High

914897

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.460

High

914898

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

0

Small-scale

0.460

High

914902

SEI1
Seipin

1

0

High-throughput

0.460

High

914903

INP54
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54

1

0

Small-scale

0.460

High

914910

TECR
Very-long-chain enoyl-CoA reductase

1

0

Small-scale

0.460

High

458588

SEC4
Ras-related protein SEC4

1

0

Small-scale

0.458

High

579739

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

754709

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

Small-scale

0.458

High

819262

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

751099

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

Small-scale

0.439

High

367252

ATP6
ATP synthase subunit a

1

1

Small-scale

0.437

High

750976

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

Small-scale

0.437

High

814185

SEC72
Translocation protein SEC72

1

0

Small-scale

0.426

High

914892

SC6B2
Protein transport protein SBH2

1

0

Small-scale

0.426

High

150210

CCW14
Covalently-linked cell wall protein 14

1

0

Small-scale

0.251

Low

358276

ADH1
Alcohol dehydrogenase 1

1

0

Small-scale

0.251

Low

628082

FKBP
FK506-binding protein 1

1

0

Small-scale

0.251

Low

642424

MCK1
Protein kinase MCK1

1

0

Small-scale

0.251

Low

698148

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

Small-scale

0.251

Low

746297

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

Small-scale

0.251

Low

781516

YKR18
IML2-like protein YKR018C

1

0

Small-scale

0.251

Low

808990

HXT7
High-affinity hexose transporter HXT7

1

0

Small-scale

0.251

Low

812917

UIP3
ULP1-interacting protein 3

1

0

High-throughput

0.251

Low

850395

YFI6
Uncharacterized protein YFR016C

1

0

Small-scale

0.251

Low

444572

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

646735

SEC15
Exocyst complex component SEC15

1

0

Small-scale

0.249

Low

746171

SEC8
Exocyst complex component SEC8

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025