HitPredict

Interactor 1: PI15 (O43692)
Peptidase inhibitor 15 (PI-15) (25 kDa trypsin inhibitor) (p25TI) (Cysteine-rich secretory protein 8) (CRISP-8) (SugarCrisp)
Gene: PI15

Interactor 2: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 258 Hs			1 1613
+	Hs
		270260 CRIS2_HUMAN (65-254): 1.62e-60: 193: 28.21		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		211335 PI15_HUMAN (1-258): 8.27e-106: 308: 100.00		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		258293 CRIS2_HUMAN (65-254): 1.62e-60: 193: 28.21		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		211341 PI15_HUMAN (1-258): 8.27e-106: 308: 100.00		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		211388 PI15_HUMAN (1-258): 8.27e-106: 308: 100.00		SORL_HUMAN (1169-1391): 5.2e-22: 106: 19.56