HitPredict

Interactor 1: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Interactor 2: TLR8 (Q9NR97)
Toll-like receptor 8 (CD antigen CD288)
Gene: TLR8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, LRR_8~ig, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Hs			1 1041
+	Hs
		1344389 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR8_HUMAN (1-1041): 0: 564: 100.00
+	Mm
		885977 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR8_MOUSE (1-1041): 8.12e-168: 522: 70.32
+	Hs
		120114 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR4_HUMAN (37-542): 3.3e-37: 153: 17.44
+	Hs
		211422 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR10_HUMAN (37-567): 2.13e-23: 109: 17.82
+	Hs
		179919 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR3_HUMAN (385-771): 2.58e-21: 102: 17.38
+	Mm
		1265201 SIG12_MOUSE (28-453): 2.65e-74: 242: 44.12		TLR4_MOUSE (37-623): 2.74e-39: 159: 18.87
+	Mm
		1162020 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR4_MOUSE (37-623): 2.74e-39: 159: 18.87
+	Hs
		120187 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR4_HUMAN (37-542): 3.3e-37: 153: 17.44
+	Hs
		211423 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR9_HUMAN (1-244): 9.75e-17: 87.6: 18.12
+	Hs
		120185 SIGL7_HUMAN (23-453): 3.93e-74: 241: 50.11		TLR4_HUMAN (37-542): 3.3e-37: 153: 17.44
+	Hs
		1348546 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR7_HUMAN (1-647): 1.96e-34: 145: 15.70
+	Hs
		211412 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR5_HUMAN (591-775): 1.22e-09: 64.5: 21.28
+	Hs
		1073338 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR1_HUMAN (42-566): 4.99e-25: 114: 13.99
+	Mm
		1162021 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR2_MOUSE (9-597): 7.69e-26: 116: 16.13
+	Hs
		1315643 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR10_HUMAN (37-567): 2.13e-23: 109: 17.82
+	Hs
		179970 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR3_HUMAN (385-771): 2.58e-21: 102: 17.38
+	Hs
		1344383 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR9_HUMAN (1-244): 9.75e-17: 87.6: 18.12
+	Mm
		1162019 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR1_MOUSE (41-482): 2.82e-13: 76.4: 16.74
+	Hs
		237442 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR5_HUMAN (591-775): 1.22e-09: 64.5: 21.28
+	Hs
		237523 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR2_HUMAN (596-770): 3.38e-09: 62.9: 23.30