HitPredict

Interactor 1: AP1G1 (O43747)
AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)
Gene: AP1G1

Interactor 2: EPN4 (Q14677)
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)
Gene: CLINT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	15758025, 12429846, 12538641
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016020 - membrane GO:0043231 - intracellular membrane-bounded organelle GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 625
+	Hs
		321545 AP2A1_HUMAN (3-808): 0: 594: 24.39		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	Hs
		302148 AP2A2_HUMAN (3-813): 0: 582: 24.55		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	Hs
		925867 AP2B1_HUMAN (30-800): 0: 552: 16.59		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	At
		1195469 AP1G1_ARATH (5-817): 0: 694: 44.46		EPN1_ARATH (7-421): 1.05e-66: 229: 21.81
+	Rn
		88757 D3ZUY8_RAT (3-808): 0: 594: 24.68		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Hs
		321680 AP2A1_HUMAN (3-808): 0: 594: 24.39		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	Rn
		291387 AP2A2_RAT (3-808): 0: 585: 24.82		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Rn
		291395 Q66HM2_RAT (3-808): 0: 584: 24.67		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Sc
		812546 AP1G1_YEAST (5-806): 0: 548: 30.83		ENT3_YEAST (2-385): 3.45e-84: 271: 24.94
+	Hs
		302230 AP2A2_HUMAN (3-813): 0: 582: 24.55		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	Rn
		923862 AP2B1_RAT (30-800): 0: 552: 16.59		EPN2_RAT (8-556): 7.08e-74: 249: 19.17
+	Dm
		954828 AP2A_DROME (3-807): 0: 562: 22.73		Q7KU90_DROME (6-624): 1.54e-65: 232: 21.07
+	Rn
		291389 AP2B1_RAT (30-800): 0: 552: 16.59		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Hs
		926065 AP2B1_HUMAN (30-800): 0: 552: 16.59		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	At
		1228257 AP2A1_ARATH (1-804): 0: 553: 24.53		EPN1_ARATH (7-421): 1.05e-66: 229: 21.81
+	Hs
		307524 AP2B1_HUMAN (30-800): 0: 552: 16.59		EPN2_HUMAN (8-595): 6.55e-52: 191: 20.40
+	Hs
		203194 AP2A1_HUMAN (3-808): 0: 594: 24.39		SYNJ1_HUMAN (120-617): 7.92e-35: 143: 10.29
+	At
		1147101 AP2A1_ARATH (1-804): 0: 553: 24.53		EPN2_ARATH (7-612): 4.91e-48: 182: 17.53
+	Hs
		203219 AP2B1_HUMAN (30-800): 0: 552: 16.59		SYNJ1_HUMAN (120-617): 7.92e-35: 143: 10.29
+	Rn
		1144064 Q66HM2_RAT (3-808): 0: 584: 24.67		SYNJ1_RAT (314-625): 4.54e-10: 65: 10.35