HitPredict

Interactor 1: TLX2 (O43763)
T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)
Gene: TLX2

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	35140242, 20211142
Identification Methods	proximity labelling technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 770
+	Hs
		211837 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		974243 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		213323 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		679096 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		211840 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		679098 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		213322 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		211839 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		974244 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		679097 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		211838 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Hs
		213326 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		211844 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		974247 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		213284 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		211960 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Hs
		211773 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		223203 TLX3_MOUSE (6-273): 2.36e-41: 146: 57.91		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		245566 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		211820 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37