HitPredict

Interactor 1: CREB3 (O43889)
Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]
Gene: CREB3

Interactor 2: ZHANG (Q9NS37)
CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)
Gene: CREBZF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

The method score is based on:

Property	Details
Experiments	15705566, 23661758
Identification Methods	anti bait coimmunoprecipitation, fluorescent resonance energy transfer
Interaction Type	direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 4 others more... GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0090575 - RNA polymerase II transcription regulator complex GO:0140467 - integrated stress response signaling
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	371
Hs

1	354

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024