HitPredict

Interactor 1: MED7 (O43513)
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
Gene: MED7

Interactor 2: MED10 (Q9BTT4)
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)
Gene: MED10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 24981860, 33961781, 15175163, 35271311, 15989967, 10882111, 14576168, 24882805
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med10~Med7
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0016592 - mediator complex and 6 others more... GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0035019 - somatic stem cell population maintenance GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061630 - ubiquitin protein ligase activity GO:0070847 - core mediator complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	233
Hs

1	135

Service provided by Combinatics, Japan

Last updated: 11Aug2025