Protein: MED7
Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7)

Gene: MED7
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: Q08278

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062901

MED4
Mediator of RNA polymerase II transcription subunit 4

16

1

Small-scale

0.984

High

867878

MED21
Mediator of RNA polymerase II transcription subunit 21

15

1

Small-scale

0.983

High

740437

MED17
Mediator of RNA polymerase II transcription subunit 17

13

2

Small-scale

0.978

High

801166

MED31
Mediator of RNA polymerase II transcription subunit 31

9

4

Small-scale

0.971

High

619449

MED14
Mediator of RNA polymerase II transcription subunit 14

10

3

Small-scale

0.969

High

797720

MED8
Mediator of RNA polymerase II transcription subunit 8

10

2

Small-scale

0.967

High

1054354

MED10
Mediator of RNA polymerase II transcription subunit 10

9

6

Small-scale

0.967

High

668501

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.881

High

740816

MED18
Mediator of RNA polymerase II transcription subunit 18

16

1

Small-scale

0.761

High

402139

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.754

High

733562

MED16
Mediator of RNA polymerase II transcription subunit 16

8

1

Small-scale

0.746

High

804033

MED6
Mediator of RNA polymerase II transcription subunit 6

8

4

Small-scale

0.744

High

1062900

MED1
Mediator of RNA polymerase II transcription subunit 1

11

0

Small-scale

0.721

High

751218

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.720

High

624948

MED15
Mediator of RNA polymerase II transcription subunit 15

8

0

Small-scale

0.714

High

917289

MED5
Mediator of RNA polymerase II transcription subunit 5

7

0

Small-scale

0.713

High

1062898

MED2
Mediator of RNA polymerase II transcription subunit 2

8

0

Small-scale

0.713

High

1062904

MED11
Mediator of RNA polymerase II transcription subunit 11

7

0

Small-scale

0.710

High

740476

MED22
Mediator of RNA polymerase II transcription subunit 22

7

0

Small-scale

0.708

High

757596

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

Small-scale

0.696

High

678819

SRB8
Mediator of RNA polymerase II transcription subunit 12

4

4

Small-scale

0.691

High

823231

MED3
Mediator of RNA polymerase II transcription subunit 3

6

0

Small-scale

0.686

High

807853

SSN2
Mediator of RNA polymerase II transcription subunit 13

5

0

Small-scale

0.684

High

810673

SSN3
Meiotic mRNA stability protein kinase SSN3

3

4

Small-scale

0.646

High

1036351

ADA2
SAGA complex subunit ADA2

2

3

High-throughput

0.621

High

1062896

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

Small-scale

0.618

High

393446

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.608

High

594607

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

760545

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

2

2

High-throughput

0.567

High

916610

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

High-throughput

0.563

High

1039057

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

763384

TAF14
Transcription initiation factor TFIID subunit 14

2

0

Small-scale

0.559

High

525373

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.552

High

546544

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

518409

IF4A
ATP-dependent RNA helicase eIF4A

2

2

High-throughput

0.537

High

792456

BOI1
BEM1-interacting protein 1

1

1

High-throughput

0.494

High

672081

BUD31
Pre-mRNA-splicing factor BUD31

1

0

High-throughput

0.486

High

381296

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

382389

H4
Histone H4

1

0

Small-scale

0.480

High

1062773

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.480

High

614852

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

3

Small-scale

0.479

High

643670

SNF2
Transcription regulatory protein SNF2

1

1

Small-scale

0.479

High

743056

SWI3
SWI/SNF complex subunit SWI3

1

3

Small-scale

0.479

High

743148

STH1
Nuclear protein STH1/NPS1

1

1

Small-scale

0.479

High

745623

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

1

Small-scale

0.479

High

849630

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

1

Small-scale

0.479

High

850592

RSC8
Chromatin structure-remodeling complex protein RSC8

1

3

Small-scale

0.479

High

867865

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

3

High-throughput

0.479

High

922149

SNF12
Transcription regulatory protein SNF12

1

2

Small-scale

0.479

High

1054041

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

2

Small-scale

0.479

High

408444

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.460

High

917740

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.460

High

483808

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.458

High

603120

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

617820

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

708385

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

764167

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

776661

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

858366

SAC3
Nuclear mRNA export protein SAC3

1

0

Small-scale

0.458

High

865769

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

919697

RT102
Regulator of Ty1 transposition protein 102

1

0

Small-scale

0.458

High

921031

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

Small-scale

0.458

High

1050601

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.458

High

1061377

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

Small-scale

0.458

High

1062897

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

1062899

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1062902

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

1062903

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

792986

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.457

High

527864

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

742551

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

804515

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

819986

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

798169

ARPC1
Actin-related protein 2/3 complex subunit 1

1

1

Small-scale

0.437

High

1035342

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

2

Small-scale

0.437

High

1055160

CORO
Coronin-like protein

1

1

Small-scale

0.437

High

1055385

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

3

Small-scale

0.437

High

486336

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

1042391

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

580180

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

734218

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

810913

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

836929

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

358353

ADH1
Alcohol dehydrogenase 1

2

0

High-throughput

0.307

High

365703

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.307

High

368072

ENO2
Enolase 2

2

0

High-throughput

0.307

High

572656

ALF
Fructose-bisphosphate aldolase

2

0

High-throughput

0.307

High

825646

PUP1
PUP1 protein homolog

2

0

High-throughput

0.307

High

850311

FAR7
Factor arrest protein 7

1

0

High-throughput

0.282

High

569872

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

715022

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.265

Low

736145

ARP2
Actin-related protein 2

1

0

Small-scale

0.249

Low

750346

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.249

Low

825854

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.249

Low

865591

ARP3
Actin-related protein 3

1

0

Small-scale

0.249

Low

922987

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

1052973

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.249

Low

743488

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.238

Low

798003

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

712683

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

893242

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025