Protein: MED10
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Negative regulator of URS2 protein 2)

Gene: MED10, NUT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 45
UniProt ID: Q06213

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054354

MED7
Mediator of RNA polymerase II transcription subunit 7

9

6

Small-scale

0.967

High

619446

MED14
Mediator of RNA polymerase II transcription subunit 14

8

3

Small-scale

0.966

High

867877

MED21
Mediator of RNA polymerase II transcription subunit 21

8

0

Small-scale

0.917

High

804032

MED6
Mediator of RNA polymerase II transcription subunit 6

3

4

Small-scale

0.843

High

668500

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.836

High

801162

MED31
Mediator of RNA polymerase II transcription subunit 31

5

2

Small-scale

0.717

High

740814

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

Small-scale

0.697

High

797719

MED8
Mediator of RNA polymerase II transcription subunit 8

4

1

Small-scale

0.696

High

740474

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

1054360

MED4
Mediator of RNA polymerase II transcription subunit 4

5

0

Small-scale

0.676

High

740434

MED17
Mediator of RNA polymerase II transcription subunit 17

4

0

Small-scale

0.657

High

1054356

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

High-throughput

0.654

High

751217

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.653

High

624945

MED15
Mediator of RNA polymerase II transcription subunit 15

3

0

Small-scale

0.625

High

917288

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

Small-scale

0.622

High

1054359

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

Small-scale

0.622

High

810668

SSN3
Meiotic mRNA stability protein kinase SSN3

2

3

Small-scale

0.611

High

678817

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

3

Small-scale

0.595

High

867862

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

2

Small-scale

0.595

High

708238

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.581

High

733560

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.576

High

757595

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.576

High

823225

MED3
Mediator of RNA polymerase II transcription subunit 3

2

0

High-throughput

0.576

High

1054362

MED11
Mediator of RNA polymerase II transcription subunit 11

2

0

High-throughput

0.576

High

807849

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.569

High

763025

SPT7
SAGA complex subunit SPT7

1

2

High-throughput

0.536

High

448806

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.518

High

584455

IDI1
Isopentenyl-diphosphate delta-isomerase

1

0

High-throughput

0.518

High

594577

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.501

High

680080

CDC48
Cell division control protein 48

1

0

High-throughput

0.493

High

757907

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.493

High

805640

LSM12
Protein LSM12

1

0

High-throughput

0.493

High

598441

TUP1
General transcriptional corepressor TUP1

1

2

Small-scale

0.481

High

1054361

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.481

High

744574

TOA1
Transcription initiation factor IIA large subunit

1

0

Small-scale

0.480

High

864434

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

776652

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

763378

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

764159

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

800767

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

1054355

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

1054357

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

381273

H2B1
Histone H2B.1

1

1

High-throughput

0.445

High

1054358

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.445

High

1046935

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025