HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: HXD8 (P13378)
Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4)
Gene: HOXD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 290
+	Hs
		222113 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		Q6FHY5_HUMAN (10-281): 4.37e-30: 116: 19.85
+	Hs
		222035 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		HXA1_HUMAN (1-270): 1.32e-28: 113: 20.54
+	Hs
		593925 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		HXC8_HUMAN (1-265): 3.3e-34: 126: 46.04
+	Hs
		222003 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		HXC4_HUMAN (173-256): 6.45e-17: 80.5: 52.13
+	Hs
		222131 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		Q86TF7_HUMAN (173-256): 7.12e-17: 80.1: 52.13
+	Hs
		440401 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		HXC8_HUMAN (1-265): 3.3e-34: 126: 46.04
+	Hs
		440400 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		HXA9_HUMAN (1-262): 8.95e-34: 125: 22.26
+	Hs
		699648 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		HXA1_HUMAN (1-270): 1.32e-28: 113: 20.54
+	Hs
		557127 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		HXC8_HUMAN (1-265): 3.3e-34: 126: 46.04
+	Hs
		440597 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		Q6FHY5_HUMAN (10-281): 4.37e-30: 116: 19.85
+	Hs
		463288 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		HXB5_HUMAN (1-272): 2.75e-29: 113: 25.54
+	Hs
		440306 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		HXB5_HUMAN (1-272): 2.75e-29: 113: 25.54
+	Hs
		725036 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		HXC8_HUMAN (1-265): 3.3e-34: 126: 46.04
+	Hs
		462951 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		HXB5_HUMAN (1-272): 2.75e-29: 113: 25.54
+	Hs
		478653 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		HXB5_HUMAN (1-272): 2.75e-29: 113: 25.54
+	Hs
		463287 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		HXC4_HUMAN (173-256): 6.45e-17: 80.5: 52.13