HitPredict

Interactor 1: IKBE (O54910)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: Nfkbie

Interactor 2: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	9405619
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051059 - NF-kappaB binding GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 364 Mm			1 549
+	Mm
		978991 IKBA_MOUSE (103-360): 6.82e-78: 243: 34.22		TF65_MOUSE (1-549): 0: 662: 100.00
+	Rn
		1144369 IKBA_RAT (103-360): 1.86e-77: 242: 34.22		Q7TQN4_RAT (1-549): 0: 659: 96.00
+	Hs
		639733 IKBA_HUMAN (44-360): 1.52e-81: 253: 30.21		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		121585 IKBE_HUMAN (1-364): 2.15e-77: 248: 81.37		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		639734 IKBA_HUMAN (44-360): 1.52e-81: 253: 30.21		REL_HUMAN (12-491): 8.06e-158: 465: 42.89
+	Hs
		121586 IKBE_HUMAN (1-364): 2.15e-77: 248: 81.37		REL_HUMAN (12-491): 8.06e-158: 465: 42.89
+	Hs
		639731 IKBA_HUMAN (44-360): 1.52e-81: 253: 30.21		RELB_HUMAN (7-453): 8.96e-153: 451: 39.20
+	Mm
		638475 IKBA_MOUSE (103-360): 6.82e-78: 243: 34.22		NFKB1_MOUSE (6-485): 5.81e-151: 459: 28.96
+	Hs
		121584 IKBE_HUMAN (1-364): 2.15e-77: 248: 81.37		RELB_HUMAN (7-453): 8.96e-153: 451: 39.20
+	Mm
		546810 IKBA_MOUSE (103-360): 6.82e-78: 243: 34.22		REL_MOUSE (12-491): 5.26e-154: 455: 42.25
+	Hs
		587427 IKBA_HUMAN (44-360): 1.52e-81: 253: 30.21		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Mm
		981551 IKBA_MOUSE (103-360): 6.82e-78: 243: 34.22		RELB_MOUSE (13-453): 7.12e-150: 443: 38.54
+	Hs
		121567 IKBE_HUMAN (1-364): 2.15e-77: 248: 81.37		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Hs
		639729 IKBA_HUMAN (44-360): 1.52e-81: 253: 30.21		NFKB2_HUMAN (6-418): 9.56e-141: 430: 33.79
+	Mm
		222602 IKBE_MOUSE (1-364): 1.65e-74: 236: 100.00		RELB_MOUSE (13-453): 7.12e-150: 443: 38.54
+	Hs
		121583 IKBE_HUMAN (1-364): 2.15e-77: 248: 81.37		NFKB2_HUMAN (6-418): 9.56e-141: 430: 33.79
+	Dm
		957297 CACT_DROME (91-355): 4.35e-73: 237: 29.51		DIF_DROME (12-464): 1.26e-123: 379: 28.45
+	Dm
		547613 CACT_DROME (91-355): 4.35e-73: 237: 29.51		DORS_DROME (16-351): 6.51e-109: 350: 42.17
+	Dm
		974284 CACT_DROME (91-355): 4.35e-73: 237: 29.51		NFKB1_DROME (19-342): 1.04e-102: 333: 33.33
+	Mm
		1376728 IKBA_MOUSE (103-360): 6.82e-78: 243: 34.22		NFAT5_MOUSE (6-451): 3.87e-84: 287: 18.63