HitPredict

Interactor 1: BUB1 (O43683)
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)
Gene: BUB1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1085 Hs			1 457
+	Hs
		1105938 PKN2_HUMAN (217-1078): 8.89e-133: 429: 10.42		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		1038627 MYLK_HUMAN (135-1084): 1.04e-127: 431: 12.51		FKBP4_HUMAN (1-456): 4.32e-138: 406: 53.93
+	Hs
		349062 LATS1_HUMAN (111-1077): 5.37e-119: 395: 10.17		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		1106000 DCLK2_HUMAN (388-1075): 1.77e-119: 387: 11.59		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		728585 AKT2_HUMAN (743-1084): 2.94e-115: 366: 11.90		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		1105911 KCC2D_HUMAN (774-1085): 1.41e-103: 336: 14.29		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		548992 KPSH1_HUMAN (713-1084): 1.83e-81: 274: 15.07		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		170125 AURKA_HUMAN (654-1065): 8.15e-81: 271: 15.09		FKBP5_HUMAN (1-457): 6.1e-146: 426: 100.00
+	Hs
		548988 KPSH1_HUMAN (713-1084): 1.83e-81: 274: 15.07		FKBP4_HUMAN (1-456): 4.32e-138: 406: 53.93
+	Hs
		1125450 MYLK_HUMAN (135-1084): 1.04e-127: 431: 12.51		FKBP8_HUMAN (25-330): 2.67e-27: 114: 19.23
+	Hs
		731338 PKN2_HUMAN (217-1078): 8.89e-133: 429: 10.42		STIP1_HUMAN (265-457): 4.42e-23: 103: 17.62
+	Hs
		124726 KPSH1_HUMAN (713-1084): 1.83e-81: 274: 15.07		AIP_HUMAN (144-414): 3.07e-49: 172: 16.72
+	Hs
		731268 KCC2D_HUMAN (774-1085): 1.41e-103: 336: 14.29		STIP1_HUMAN (265-457): 4.42e-23: 103: 17.62
+	Hs
		996416 KCC2D_HUMAN (774-1085): 1.41e-103: 336: 14.29		FKB1B_HUMAN (41-138): 1.44e-24: 99.4: 50.00